Document Detail

DeLIMiting development.
MedLine Citation:
PMID:  9504048     Owner:  NLM     Status:  MEDLINE    
LIM-homeodomain transcription factors (LIM-HD) regulate expression of genes that pattern the body and generate cell specificity during development in invertebrates and vertebrates. It is especially interesting that most are expressed in and participate in the development of the nervous system. LIM-HD proteins are themselves regulated by both intramolecular and intermolecular interactions mediated by the LIM domains. LIM domains positively regulate LIM-HD activity by promoting protein-protein interactions that allow cooperative binding to regulatory regions of tissue-specific promoters. They also negatively regulate LIM-HD activity, possibly by preventing HD association with DNA. Interaction of LIM domains with other proteins relieves this interference, permitting DNA binding and providing a mechanism for refining LIM-HD activity. The recurrence of LIM-HD proteins in fundamental developmental processes emphasizes the importance of their function and regulation and provides an opportunity to identify mechanisms and molecules underlying patterning and cell specification.
J Curtiss; J S Heilig
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  20     ISSN:  0265-9247     ISO Abbreviation:  Bioessays     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-13     Completed Date:  1998-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  58-69     Citation Subset:  IM    
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347, USA.
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MeSH Terms
Amino Acid Sequence
Embryonic and Fetal Development
Gene Expression Regulation, Developmental
Homeodomain Proteins / chemistry,  genetics,  physiology*
Molecular Sequence Data
Nervous System / growth & development
Sequence Homology, Amino Acid
Transcription Factors / chemistry,  genetics,  physiology*
Reg. No./Substance:
0/Homeodomain Proteins; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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