| De subitaneis mortibus. X. Familial congential heart block. | |
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MedLine Citation:
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PMID: 1112019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complete heart block was found shortly after birth in a brother and sister (not twins). Both were treated by electronic pacing because of symptoms attributable to inadequate cardiac output and electrical instability of heart. The boy has done well with his artificial pacemaker and is now six years old. His sister died of complications due in part to the large size of her pacemaker and small size of her body. At necropsy special studies of her heart included the centers for normal impulse formation and concuction. The primary abnormalities were at the junction of atrial septum with atrioventricular (A-V) node, and at the origin of the two bundle branches from the His bundle. The A-V node was isolated by collagen at all its margins except its junction with the His bundle. The proximal His bundle was essentially normal, but from that point on through the initial protions of both the left and right bundle branches there was extensive caseous degeneration which interrupted any possible conduction. These findings are discussed in relation to fetal and postnatal development of the human A-V node, and the His bundle and its branches; and in the context of a recently observed mathematical relationship between sinus rate and two forms of experimentally produced A-V junctional escape rhythms. |
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Authors:
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T N James; R C McKone; A S Hudspeth |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 51 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-05-10 Completed Date: 1975-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 379-88 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrioventricular Node
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pathology,
physiopathology Autopsy Bundle of His / pathology, physiopathology Cardiac Output Female Heart Block / congenital, genetics*, therapy Heart Conduction System / abnormalities*, pathology, physiopathology Heart Defects, Congenital / complications* Humans Infant, Newborn Male Myocardium / pathology Necrosis Organ Size Pacemaker, Artificial* / adverse effects Pericarditis / complications, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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