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De novo hairy cell leukemia with a major BCR/ABL1 rearrangement: A case report with a literature review.
MedLine Citation:
PMID:  24698424     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hairy cell leukemia (HCL) is a very rare mature B-cell neoplasm and its simultaneous occurrence with chronic myeloid leukemia has been reported in only three cases. The pathogenesis and relationship of the two diseases are not clear. Here we report a case of HCL expressing a BCR/ABL1 clone, which showed molecular remission of the fusion clones and achieved partial remission over nine months of cladribine therapy. After a thorough analysis of previous studies and the results of this patient, we speculate that a subclone evolved to have an additional genetic BCR/ABL1 rearrangement. We also review all published literature on HCL with BCR/ABL1 rearrangement and discuss the pathophysiology of these unusual cases.
Authors:
Young-Woong Won; Sung Jong Kim; Tae Sung Park; Seung Hwan Oh; Thomas S K Wan; Eun Jung Baek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  64     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  142-7     Citation Subset:  IM    
Copyright Information:
© 2014 The Authors. Pathology International © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
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