Document Detail

De novo formation of a distinct coronary vascular population in neonatal heart.
MedLine Citation:
PMID:  24994653     Owner:  NLM     Status:  In-Data-Review    
The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease.
Xueying Tian; Tianyuan Hu; Hui Zhang; Lingjuan He; Xiuzhen Huang; Qiaozhen Liu; Wei Yu; Liang He; Zhen Yang; Yan Yan; Xiao Yang; Tao P Zhong; William T Pu; Bin Zhou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  345     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2014, American Association for the Advancement of Science.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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