| De novo chemoenzymatic synthesis of sialic acid. | |
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MedLine Citation:
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PMID: 23128386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A chemoenzymatic synthesis of sialic acid from inexpensive N-acetyl-d-glucosamine is described. In a three-step Wittig-protection-ozonolysis strategy manno-configured aldehydes are obtained. Treatment with oxaloacetate in the presence of macrophomate synthase affords the signature α-keto-γ-hydroxy acid moiety with high diastereoselectivity. |
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Authors:
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Pierre Stallforth; Stefan Matthies; Alexander Adibekian; Dennis G Gillingham; Donald Hilvert; Peter H Seeberger |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-5 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany and Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany. peter.seeberger@mpikg.mpg.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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