| 'De novo' absence status of late onset: report of 11 cases. | |
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MedLine Citation:
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PMID: 1734289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Absence status (AS) is a heterogenous epileptic syndrome that can occur at any age, usually in a context of prior epilepsy. Eleven cases of AS occurring in middle-aged patients who had no history of epilepsy were retrospectively collected over a 10-year period (10 women and one man; mean age, 58.6 years). Eight patients were receiving high doses of psychotropic drugs. Clinical and EEG presentation was similar to AS occurring in patients with prior epilepsy. Evaluation of precipitating factors revealed that AS coincided with benzodiazepine withdrawal in eight cases. Cofactors included excessive use of other psychotropic drugs, nonpsychotropic treatment, hypocalcemia, hyponatremia, and chronic alcoholism. CT demonstrated mild cerebral atrophy in six cases. There was no recurrence, even without chronic antiepileptic treatment. These data indicate that (1) most cases of "de novo" AS of middle age or late onset result from the addition of various epileptogenic factors; (2) AS can be considered a new and uncommon complication of benzodiazepine withdrawal, and (3) long-term administration of anticonvulsant medication may not be required. |
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Authors:
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P Thomas; A Beaumanoir; P Genton; C Dolisi; M Chatel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 42 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-03-02 Completed Date: 1992-03-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 104-10 Citation Subset: AIM; IM |
Affiliation:
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Service de Neurologie, Hôpital Pasteur, Nice, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Electroencephalography Epilepsy, Absence / diagnosis, etiology, physiopathology* Female Humans Male Middle Aged Movement Prognosis Psychotropic Drugs / adverse effects Substance Withdrawal Syndrome / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs |
| Comments/Corrections | |
Comment In:
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Neurology. 1993 Feb;43(2):452-3
[PMID:
8437725
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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