Document Detail

'De novo' absence status of late onset: report of 11 cases.
MedLine Citation:
PMID:  1734289     Owner:  NLM     Status:  MEDLINE    
Absence status (AS) is a heterogenous epileptic syndrome that can occur at any age, usually in a context of prior epilepsy. Eleven cases of AS occurring in middle-aged patients who had no history of epilepsy were retrospectively collected over a 10-year period (10 women and one man; mean age, 58.6 years). Eight patients were receiving high doses of psychotropic drugs. Clinical and EEG presentation was similar to AS occurring in patients with prior epilepsy. Evaluation of precipitating factors revealed that AS coincided with benzodiazepine withdrawal in eight cases. Cofactors included excessive use of other psychotropic drugs, nonpsychotropic treatment, hypocalcemia, hyponatremia, and chronic alcoholism. CT demonstrated mild cerebral atrophy in six cases. There was no recurrence, even without chronic antiepileptic treatment. These data indicate that (1) most cases of "de novo" AS of middle age or late onset result from the addition of various epileptogenic factors; (2) AS can be considered a new and uncommon complication of benzodiazepine withdrawal, and (3) long-term administration of anticonvulsant medication may not be required.
P Thomas; A Beaumanoir; P Genton; C Dolisi; M Chatel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  42     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-02     Completed Date:  1992-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-10     Citation Subset:  AIM; IM    
Service de Neurologie, Hôpital Pasteur, Nice, France.
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MeSH Terms
Aged, 80 and over
Epilepsy, Absence / diagnosis,  etiology,  physiopathology*
Middle Aged
Psychotropic Drugs / adverse effects
Substance Withdrawal Syndrome / physiopathology
Reg. No./Substance:
0/Psychotropic Drugs
Comment In:
Neurology. 1993 Feb;43(2):452-3   [PMID:  8437725 ]

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