Document Detail

De novo development of heart valve calcification in incident peritoneal dialysis patients.
MedLine Citation:
PMID:  24211754     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Cardiac valve calcification (VC) is a frequent complication in chronic kidney disease and is considered a risk factor for all-cause and cardiovascular mortality. However, little is known about the pathophysiology mechanisms that originate it and the factors associated with its development. We undertook this study to analyze the frequency and factors related to de novo development of mitral valve calcification (MVC) and aortic valve calcifications (AVC) in incident peritoneal dialysis (PD) patients.
METHODS: A prospective cohort of 124 incident PD patients was studied. Demographic and clinical data were recorded and blood assayed at baseline and after 1 year of follow-up for calcium, phosphorus, glucose, urea, creatinine, cholesterol, triglycerides by spectrophotometry assay; high-sensitivity C-reactive protein (CRP) by immunoturbidimetric ultrasensitive assay, intact parathormone (iPTH) and osteocalcin by electrochemiluminescence, fetuin-A and osteoprotegerin by EDI-ELISA. Valve calcification was evaluated by M-mode bidimensional echocardiogram.
RESULTS: Sixty eight percent of patients were male, ages 43 ± 13 years; 51% were diabetic with 1.4 ± 1 months on PD. After 12.3 ± 1 months, 57 patients (46%) developed VC: AVC in 33 (57.8%), MVC in 15 (26.3%) and 9 (15.8%) patients in both valves. There was no correlation between AVC and MCV. In univariate logistic regression analysis, age, diabetes and elevated concentrations of OPG, iPTH and CRP were risk factors for development MVC. In multivariate analysis, only iPTH remained an independent risk factor as was also the case in AVC.
CONCLUSIONS: Age, diabetes, osteoprotegerin, parathormone and C-reactive protein are risk factors related to de novo development of MVC and iPTH for AVC in incident dialysis patients.
Marcela Avila-Díaz; Carmen Mora-Villalpando; Ma Del Carmen Prado-Uribe; Oscar Orihuela-Rodriguez; Edgar Villegas-Antelo; Ana Ma Gómez-Noriega; Diana Villanueva-Noches; Hector Hinojosa-Heredia; Héctor Hinojosa-Hernandez; Juan Serrato-Avila; Begoña Ilabaca; Ramón Paniagua
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-11-08
Journal Detail:
Title:  Archives of medical research     Volume:  44     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-12-09     Completed Date:  2014-03-27     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 IMSS. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
C-Reactive Protein / metabolism
Heart Valve Diseases / blood,  complications*,  physiopathology*
Middle Aged
Mitral Valve / metabolism,  physiopathology*
Parathyroid Hormone-Related Protein / adverse effects,  blood
Peritoneal Dialysis / adverse effects
Prospective Studies
Renal Dialysis / adverse effects
Risk Factors
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein; 9007-41-4/C-Reactive Protein
Erratum In:
Arch Med Res. 2014 Jul;45(5):443
Note: Hinojosa-Hernandez, Héctor [corrected to Hinojosa-Heredia, Hector]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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