| De-Toring high fat for a healthy heart. | |
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MedLine Citation:
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PMID: 21438808 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Evaluation of: Birse RT, Choi J, Reardon K et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell. Metab. 12, 533-544 (2010). Excessive intake of nutrients is widely believed to be one of the main contributing factors to the global epidemic of obesity. Despite extensive studies over last few decades, the genetic mechanisms that mediate high-fat diet (HFD)-induced obesity are still not clear. It is also unknown if a similar genetic mechanism underlies the cardiac dysfunction associated with HFD-induced obesity. In a recent study, Birse et al. used a Drosophila model to determine whether the ancient nutrient sensing target of rapamycin (TOR) pathway affects heart function upon challenge with a HFD. As in mammals, this study found that flies fed on HFD became obese, and displayed severe heart dysfunction. Genetic suppression of the TOR signaling pathway prevented fat accumulation and protected flies against HFD-induced cardiac defects. Together with biochemical evidence that HFD affects insulin-TOR signaling, these data suggest that deregulation of TOR activity mediates the deleterious effect of HFD on heart function. |
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Authors:
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Xiangzhong Zheng |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 9 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 299-302 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, 232 Stemmler Hall, University of Pennsylvania School of Medicine, 3450 Hamilton Walk, Philadelphia, PA 19104, USA. zhengx@mail.med.upenn.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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