Document Detail

Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress.
MedLine Citation:
PMID:  12969876     Owner:  NLM     Status:  MEDLINE    
We used mice deficient in dopamine beta-hydroxylase [Dbh(-/-)] and their littermate controls [Dbh(+/-)] to examine the role of epinephrine (Epi) and norepinephrine (NE) in the maintenance of cardiovascular parameters during 7 days of caloric restriction and acute exposure to environmental stress. Cardiovascular parameters of the mice were monitored using blood pressure radiotelemeters at an ambient temperature of 29 degrees C. Under normal conditions, Dbh(-/-) mice had a low heart rate, were severely hypotensive, and displayed an attenuated circadian blood pressure rhythm. Upon 50% caloric restriction, Dbh(+/-) mice exhibited decreases in heart rate and mean blood pressure. However, the blood pressures of Dbh(-/-) mice did not fall significantly in response to caloric restriction, and the bradycardia associated with caloric restriction was attenuated in these mice. In response to an open-field test, the blood pressure and heart rate of Dbh(+/-) mice increased substantially and rapidly, whereas Dbh(-/-) mice had blunted changes in blood pressures and no change in heart rate. These data suggest a primary role of Epi and NE in mediating the hypotension induced by dieting. Furthermore, Epi and NE play a smaller, but still significant, role in the bradycardia induced by caloric restriction. In contrast, Epi and NE are required for the tachycardia in an open field but are not required for the increase in blood pressure.
Steven J Swoap; David Weinshenker; Richard D Palmiter; Graham Garber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2003-09-11
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  286     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-08     Completed Date:  2004-02-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R108-13     Citation Subset:  IM    
Department of Biology, Williams College, Williamstown, MA 01267, USA.
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MeSH Terms
Blood Pressure*
Caloric Restriction*
Circadian Rhythm*
Dopamine beta-Hydroxylase / deficiency*
Epinephrine / physiology*
Heart Rate*
Hypotension / enzymology,  physiopathology*
Mice, Knockout
Norepinephrine / physiology*
Stress, Physiological / physiopathology*
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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