Document Detail


Daytime melatonin treatment influences food carrying (hoarding) behavior in rats.
MedLine Citation:
PMID:  18333703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Three experiments were performed to verify whether melatonin (MEL) may influence hoarding behavior in rats. This hypothesis was supported by the consideration that leptin treatment decreases food hoarding in hamsters and that an inverse relation exists between plasma leptin concentration and MEL treatment. METHODS: Male Sprague-Dawley rats housed individually and kept on 12h:12h light-dark cycle were used. First experiment was performed to check whether a bimodal distribution of food hoarding scores exists in rats, and to select two groups of high (HH-rats) or low (LH-rats) hoarding. Second experiment was designed to verify whether MEL treatment modifies food-hoarding, while the third one was performed to investigate whether MEL treatment was able to modify the reciprocal relation between leptin and MEL plasma concentration. RESULTS: In rats the hoarding tendency fell into a bimodal distribution and the plasma leptin concentration was significantly higher in HH-rats than LH-rats. When MEL was injected, circulating concentration of leptin was decreased in both HH-rats and LH-rats and such MEL treatment significantly increased the number of pellets hoarded by LH-rats but not that hoarded by HH-rats. CONCLUSIONS: MEL influences the food-hoarding in rats either directly, or indirectly by the MEL and leptin reciprocal interaction. Our results support the hypothesis that the endocrine system either directly, by the action of one or more combined hormones (MEL, leptin), or indirectly via its actions on neural substrates determines, at least in part, food-hoarding of rats.
Authors:
G Scalera; C Benassi; A Bigiani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Endocrine regulations     Volume:  42     ISSN:  1210-0668     ISO Abbreviation:  Endocr Regul     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112018     Medline TA:  Endocr Regul     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  3-11     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, 41100 Modena, Italy. scalera@unimore.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Circadian Rhythm / physiology*
Drinking / drug effects
Drug Administration Schedule
Eating / drug effects
Feeding Behavior / drug effects*
Leptin / blood
Male
Melatonin / administration & dosage*,  blood,  pharmacology
Photoperiod*
Rats
Rats, Sprague-Dawley
Time Factors
Chemical
Reg. No./Substance:
0/Leptin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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