Document Detail

Day-to-day variability in acid reflux patterns using the BRAVO pH monitoring system.
MedLine Citation:
PMID:  16340628     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & GOALS: The wireless pH monitoring system such as the BRAVO pH system is a significant advancement in the evaluation of patients with gastroesophageal reflux because of its potentially better tolerability and the ability to record data over a 48-hour period. The aim of our study was to evaluate safety, performance, tolerability, and day-to-day variability in acid reflux patterns using the BRAVO pH system. METHODS: A total of 90 consecutive patients (48 men and 42 women) with persistent reflux symptoms underwent BRAVO pH capsule placement from October 2002 to August 2003 at a tertiary care hospital. The BRAVO pH capsule was deployed 6 cm proximal to the squamocolumnar junction under endoscopic guidance. The pH recordings over 48 hours were obtained after uploading data to a computer from the pager-like device that recorded pH signals from the BRAVO pH capsule. RESULTS: Successful pH data over 48 hours was obtained in 90% of patients. Nearly two thirds of patients experienced a variety of symptoms ranging from a foreign body sensation to chest discomfort or pain. Four patients had severe chest pain, 3 of whom required endoscopic removal of the BRAVO pH capsule. In 74.4% of patients, number of reflux events as well as time (%) pH<4 correlated from the first 24-hour period to the second 24-hour period. However, in 28% of patients, no predictable pattern of (%) time pH<4 in the supine position was reproduced from one 24-hour period to the next 24-hour period. CONCLUSIONS: The BRAVO pH system appears a safe and effective method of recording esophageal acid exposure. It is an acceptable alternative for patients who are unwilling or unable to tolerate nasopharyngeal catheter-based pH studies, and it has a potential advantage of the 2-day recording period.
Sushil K Ahlawat; David J Novak; Dionne C Williams; Kathleen A Maher; Franca Barton; Stanley B Benjamin
Related Documents :
7223298 - Gastric acid secretion (gas) and hiatal hernia. i. relationship between gas and oesopha...
17900268 - Clinical trial: persistent gastro-oesophageal reflux symptoms despite standard therapy ...
18595138 - Ineffective oesophageal motility: manometric subsets exhibit different symptom profiles.
16864008 - Diagnosis of cushing's syndrome: a retrospective evaluation of clinical practice.
23050768 - Anti-apolipoprotein a-1 autoantibodies as biomarker for atherosclerosis burden in patie...
16169798 - Peripheral inflammation in patients with asthmatic symptoms but normal lung function.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  40     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Division of Gastroenterology, Department of Medicine, Georgetown University Hospital, Washington, DC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Esophageal pH Monitoring / instrumentation*
Gastroesophageal Reflux / diagnosis*
Middle Aged
Monitoring, Ambulatory / instrumentation*
Patient Satisfaction
Regression Analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Helicobacter pylori: what do we still need to know?
Next Document:  Factors associated with failure of initial endoscopic hemoclip hemostasis for upper gastrointestinal...