| Day-to-day reproducibility of prolonged ambulatory colonic manometry in healthy subjects. | |
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MedLine Citation:
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PMID: 20345373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although colonic manometry provides useful information regarding colonic physiology, considerable variability has been reported both for regional motility and manometric patterns. Whether colonic manometry is reproducible is not known. METHODS: Seven healthy volunteers (three men, four women, mean age = 34 years) underwent two studies of 24-h ambulatory colonic manometry, each 2 weeks apart. Manometry was performed by placing a six-sensor solid-state probe, up to the hepatic flexure and anchored to colonic mucosa. Colonic motility was assessed by the number and area-under-curve (AUC) of pressure waves and motility patterns such as high-amplitude propagating contractions (HAPC). Waking and meal-induced gastrocolonic responses were also assessed. Paired t-test was used to examine the reproducibility and intra and interindividual variability. KEY RESULTS: The number of pressure waves and propagating pressure waves and HAPC, and AUC were similar between the two studies. Diurnal variation, waking and meal-induced gastrocolonic responses were also reproducible. There was some variability in the incidence of individual colonic motor patterns. CONCLUSIONS & INFERENCES: Colonic manometry findings were generally reproducible, particularly for the assessment of key physiologic changes, such as meal-induced gastrocolonic, HAPC, and waking responses. |
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Authors:
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S S C Rao; S Singh; R Mudipalli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 22 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-09-16 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 640-e178 Citation Subset: IM |
Affiliation:
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Division of Neurogastroenterology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa city, IA 52242, USA. satish-rao@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Colon / physiology* Data Interpretation, Statistical Eating / physiology Female Gastrointestinal Motility / physiology Humans Male Manometry / instrumentation, methods* Middle Aged Monitoring, Ambulatory / methods* Muscle Contraction / physiology Reproducibility of Results Software Wakefulness / physiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK057100-08/DK/NIDDK NIH HHS; R01 DK057100-10/DK/NIDDK NIH HHS; R01DK 57100-03/DK/NIDDK NIH HHS; RR00059/RR/NCRR NIH HHS |
| Comments/Corrections | |
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