Document Detail


Day time and night time effects of 24R,25-dihydroxycholecalciferol on renal alkaline phosphatase and gamma-glutamyltransferase activities in intact rats.
MedLine Citation:
PMID:  8000046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 24R,25-dihydroxycholecalciferol [24,25(OH)2 CC] on alkaline phosphatase (APA), gamma-glutamyltransferase (gamma-GT) and acid phosphatase (AP) activities were investigated on renal cortex slices of intact rats killed at 18h00 or at 06h00. At 06h00, three, six and nine hours after a single intraperitoneal injection of 24,25(OH)2 CC, APA activity was increased by 30%, 51% and 29%, respectively and gamma-GT activity, by 25%, 39% and 38%, as compared to their controls. AP on the other hand was not modified at all. These enzymatic stimulations were statistically higher than those measured at 18h00, respectively APA: 11%, 25%, 28% and gamma-GT: 2%, 20%, 22%. They can be explained by variations in new protein synthesis in relation with rat activity periods. Physiological significance of these renal effects remains to be elaborated.
Authors:
X D Thanh; P Boisnard; M A Khan; A Girault
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives internationales de physiologie, de biochimie et de biophysique     Volume:  102     ISSN:  0778-3124     ISO Abbreviation:  Arch Int Physiol Biochim Biophys     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111069     Medline TA:  Arch Int Physiol Biochim Biophys     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  IM    
Affiliation:
Laboratoire de Biochimie/C.H.U./Physiologie, U.F.R. Sciences Médicales/Pharmaceutiques, Angers.
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MeSH Terms
Descriptor/Qualifier:
24,25-Dihydroxyvitamin D 3 / administration & dosage*,  pharmacology
Acid Phosphatase / metabolism
Alkaline Phosphatase / metabolism*
Animals
Circadian Rhythm*
Female
Kidney Cortex / drug effects,  enzymology*
Kinetics
Rats
Rats, Sprague-Dawley
gamma-Glutamyltransferase / metabolism*
Chemical
Reg. No./Substance:
40013-87-4/24,25-Dihydroxyvitamin D 3; EC 2.3.2.2/gamma-Glutamyltransferase; EC 3.1.3.1/Alkaline Phosphatase; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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