Document Detail


Day of the dead: pseudokinases and pseudophosphatases in physiology and disease.
MedLine Citation:
PMID:  24818526     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of signaling pathways, and there is mounting evidence that they have frequently retained the ability to interact with cellular 'substrates', and can exert important roles in different diseases. However, these pseudoenzymes have traditionally received scant attention compared to classical kinases and phosphatases. In this review we explore new findings in the emerging pseudokinase and pseudophosphatase fields, and discuss their different modes of action which include exciting new roles as scaffolds, anchors, spatial modulators, traps, and ligand-driven regulators of canonical kinases and phosphatases. Thus, it is now apparent that pseudokinases and pseudophosphatases both support and drive a panoply of signaling networks. Finally, we highlight recent evidence on their involvement in human pathologies, marking them as potential novel drug targets.
Authors:
Veronika Reiterer; Patrick A Eyers; Hesso Farhan
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Publication Detail:
Type:  REVIEW     Date:  2014-5-9
Journal Detail:
Title:  Trends in cell biology     Volume:  -     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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