Document Detail

Day 4 embryo selection is equal to Day 5 using a new embryo scoring system validated in single embryo transfers.
MedLine Citation:
PMID:  18292597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Single embryo transfers (SETs) require the most viable embryo from a cohort to be selected. Day 4 embryos may provide a selection advantage similar to blastocyst transfer as embryos are replaced post-embryonic genome activation and into the uterus where they would normally reside. However, there is currently no adequate morphological system to assess Day 4 embryos. Therefore, we developed an assessment system for Day 4 embryos and retrospectively assessed Day 4 SET success rates compared with Day 5 SETs. METHODS: Embryos (n = 996 after IVF or ICSI) were assessed on Day 4 of development, prior to implementing Day 4 embryo transfers, to obtain a descriptive range of embryo morphologies observed at this time point. A morphological scoring system was developed from this. All patients having an SET after extended culture (Day 4, n = 124 or Day 5, n = 193), at Repromed, Adelaide, Australia, during June 2006-January 2007 were analysed for pregnancy outcome. Ongoing pregnancy was determined by fetal cardiac activity at 6-8 weeks after oocyte collection. RESULTS: Day 4 and 5 SETs resulted in similar ongoing pregnancy rates of 38.7% and 32.1%, respectively. CONCLUSIONS: A Day 4 scoring system was successfully developed and implemented. Day 4 SETs were found to be a viable option or alternative to Day 5 SETs with no difference in pregnancy rates.
Deanne Feil; Richard C Henshaw; Michelle Lane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2008-02-21
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  23     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1505-10     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Research Centre for Reproductive Health, The University of Adelaide, Adelaide, Australia.
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MeSH Terms
Blastomeres / ultrastructure*
Embryo Transfer / methods*
Maternal Age
Pregnancy Outcome
Pregnancy Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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