Document Detail

Day 3 embryo shape as a morphologic selection parameter in in vitro fertilization.
MedLine Citation:
PMID:  22890423     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate whether embryo shape is a useful morphologic predictor of developmental competence in IVF cycles.
METHODS: Two hundred eighteen day 3 single embryo transfer (SET) cycles and 225 day 3 double embryo transfer (DET) cycles in which only 8-cell non-fragmented embryos with symmetric blastomeres were transferred and in which the developmental fate of each embryo was known were analyzed for IVF outcomes with respect to embryo shape. Embryo shape was quantitatively calculated after digitizing embryo images using MATLAB, where a score of 1.0 represented a perfectly circular embryo.
RESULTS: The SET data did not reveal a significant impact of embryo shape on embryo developmental fate. The DET data revealed a trend toward the best outcomes in cycles where both embryos exhibited "roundness" scores in the highest tertiles (T3) for embryo shape. However only one subgroup (T2/T1-one embryo in the middle shape tertile (T2) and one in the lowest shape tertile (T1)) was associated with significantly lower odds of live-birth as compared to the referent group (T3/T3). When SET and DET data were combined, embryo shape was not found to be a predictor of IVF outcome.
CONCLUSIONS: Based on this retrospective analysis, the weak association of day 3 embryo shape with implantation potential suggests that this morphological characteristic is unlikely to be a useful additional marker for embryo selection after cell number, fragmentation, and blastomere symmetry. Further studies are planned to assess applicability of these conclusions to embryos of varying stages and grades.
Sophia C Kamran; David E Reichman; Stacey A Missmer; Katharine F Correia; Nilay Karaca; Aasia Romano; Catherine Racowsky
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-08-14
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1135-9     Citation Subset:  IM    
Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Blastocyst / cytology,  physiology*
Embryo Transfer
Fertilization in Vitro / methods*
Image Processing, Computer-Assisted
Pregnancy Rate
Preimplantation Diagnosis / methods*
Retrospective Studies
Single Embryo Transfer
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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