| Day 3 and day 5 morphological predictors of embryo viability. | |
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MedLine Citation:
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PMID: 12735868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Controlling multiple pregnancies in patients undergoing artificial reproductive procedures requires consideration of single embryo transfers. Therefore, refinements for embryo evaluation are needed that select for the most developmentally competent embryo. The present study was designed to identify day 3 and day 5 morphological predictors of viability following transfers in which the morphology and fate of each embryo was precisely determined. Assessments on day 3 included cell number, and the extent of fragmentation and asymmetry, and on day 5, the developmental stage. Embryos resulting in a viable fetus at 11 weeks gestation were considered developmentally competent. The relationships among individual and collective embryo morphological characteristics were evaluated. Analysis of the interactions among morphological characteristics of embryos transferred on day 3 enabled identification of a multivariable selection order. Assessment of day 5 embryos revealed that expanding and expanded blastocysts exhibited comparable developmental potential that was superior to that of either morulae or early blastocysts. However, expanding or expanded blastocysts derived from 7-cell or 8-cell embryos were developmentally superior to those derived from other cleavage stages, regardless of fragmentation or asymmetry. Collectively, these findings further understanding of morphological predictors of viability, thereby improving the ability to select the most viable embryo for transfer. |
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Authors:
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Catherine Racowsky; Catherine M H Combelles; Aida Nureddin; Yuying Pan; Alison Finn; Lyndon Miles; Sarah Gale; Thomas O'Leary; Katharine V Jackson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 6 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2003 Apr-May |
Date Detail:
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Created Date: 2003-05-08 Completed Date: 2003-12-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 323-31 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, ASB 1+3, Room 082, Boston, MA 02115, USA. cracowsky@partners.org |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blastocyst* DNA Fragmentation Embryo Transfer* Embryo, Mammalian / pathology, physiology* Embryonic and Fetal Development Female Fertilization in Vitro / methods* Fetal Viability Humans Maternal Age Morula* Oocytes / metabolism Pregnancy Pregnancy, High-Risk Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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