Document Detail

Day 2 transfer improves pregnancy outcome in in vitro fertilization cycles with few available embryos.
MedLine Citation:
PMID:  16730718     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Delaying ET to day 3 to optimize embryo selection is well accepted. However, in cases where there are not enough embryos to perform selection, it is not clear whether there is a difference in clinical outcomes with the day of ET. DESIGN: Cohort study. SETTING: Academic medical center. PATIENT(S): Two hundred forty-two fresh IVF/intracytoplasmic sperm injection (ICSI) cycles from 2002-2004, where all generated embryos were transferred irrespective of quality because of an extremely low number of available embryos. INTERVENTION(S): In time period 1, ET was on day 3. In time period 2, ET was on day 2. MAIN OUTCOME MEASURE(S): Patient response to stimulation was analyzed along with pregnancy outcome and implantation rate. RESULT(S): Miscarriage rates were decreased, and ongoing pregnancy rates were increased with a day 2 ET in patients <40 years of age. CONCLUSION(S): In women <40 years of age, the day of transfer is a significant predictor of clinical outcome in cases in which a low number of embryos are available for transfer. The evidence suggests that limiting embryo culture to only 2 days reduces the incidence of miscarriage and increases ongoing pregnancy rates.
Shehua Shen; Mitchell P Rosen; Anthony T Dobson; Victor Y Fujimoto; Charles E McCulloch; Marcelle I Cedars
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2006-05-30
Journal Detail:
Title:  Fertility and sterility     Volume:  86     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-50     Citation Subset:  IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, USA.
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MeSH Terms
California / epidemiology
Embryo Transfer / statistics & numerical data*
Fertilization in Vitro / methods,  statistics & numerical data*
Infertility, Female / epidemiology*,  therapy*
Outcome Assessment (Health Care) / methods*
Pregnancy Outcome / epidemiology*
Risk Assessment / methods
Risk Factors
Sample Size
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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