| Day 2 transfer improves pregnancy outcome in in vitro fertilization cycles with few available embryos. | |
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MedLine Citation:
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PMID: 16730718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Delaying ET to day 3 to optimize embryo selection is well accepted. However, in cases where there are not enough embryos to perform selection, it is not clear whether there is a difference in clinical outcomes with the day of ET. DESIGN: Cohort study. SETTING: Academic medical center. PATIENT(S): Two hundred forty-two fresh IVF/intracytoplasmic sperm injection (ICSI) cycles from 2002-2004, where all generated embryos were transferred irrespective of quality because of an extremely low number of available embryos. INTERVENTION(S): In time period 1, ET was on day 3. In time period 2, ET was on day 2. MAIN OUTCOME MEASURE(S): Patient response to stimulation was analyzed along with pregnancy outcome and implantation rate. RESULT(S): Miscarriage rates were decreased, and ongoing pregnancy rates were increased with a day 2 ET in patients <40 years of age. CONCLUSION(S): In women <40 years of age, the day of transfer is a significant predictor of clinical outcome in cases in which a low number of embryos are available for transfer. The evidence suggests that limiting embryo culture to only 2 days reduces the incidence of miscarriage and increases ongoing pregnancy rates. |
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Authors:
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Shehua Shen; Mitchell P Rosen; Anthony T Dobson; Victor Y Fujimoto; Charles E McCulloch; Marcelle I Cedars |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2006-05-30 |
Journal Detail:
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Title: Fertility and sterility Volume: 86 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-04 Completed Date: 2006-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 44-50 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult California / epidemiology Embryo Transfer / statistics & numerical data* Female Fertilization in Vitro / methods, statistics & numerical data* Humans Infertility, Female / epidemiology*, therapy* Outcome Assessment (Health Care) / methods* Pregnancy Pregnancy Outcome / epidemiology* Risk Assessment / methods Risk Factors Sample Size Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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