Document Detail


Daunomycin-induced cardiomyopathy in rabbits: isolated heart and papillary muscle energetics.
MedLine Citation:
PMID:  3959096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daunomycin was administered to one of each pair of litter mate rabbits at a weekly dosage rate of 40 mg/m2. Treated animals were killed when their pre-ejection period: left ventricular ejection time ratio (PEP:LVET) reached 0.4 and there was other evidence of cardiac abnormalities or when they had received 12 doses of daunomycin. Langendorff-perfused hearts from the treated animals had lower intrinsic heart rates (16%) and decreased coronary resistance (31%) in the arrested state. There was no significant difference between the basal metabolism of the arrested control and treated hearts but the magnitude of the activation component, measured under beating non-working conditions, was depressed by daunomycin. After the whole heart perfusion studies were complete, approximately 2 h after cardiectomy, papillary muscles were dissected out from the right ventricles and mechanical, myothermic and polarographic studies were undertaken. The resting heat production, in support of the whole heart metabolic data, was practically unchanged by the treatment regime. Peak stress development and work output were similar in both the control and treated groups. In energetic terms the slope of the relationship between total stress development and active heat production per beat was unchanged but there was a 21% depression of the activation heat component in the treated animals. Daunomycin treatment had not altered the work output per contraction or significantly changed energy output and hence mechanical efficiency was unaltered. It is clear that 2 h of Langendorff perfusion does not produce any depression of contractile or energetic properties in papillary muscles.
Authors:
C L Gibbs; G Kotsanas; W R Gibson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  18     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-06     Completed Date:  1986-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature Regulation
Cardiomyopathies / chemically induced*,  physiopathology
Coronary Vessels / physiopathology
Daunorubicin*
Electrocardiography
Energy Metabolism*
Heart / physiopathology*
Heart Rate
Oxygen Consumption
Papillary Muscles / physiopathology*
Perfusion
Rabbits
Stroke Volume
Thermodynamics
Vascular Resistance
Chemical
Reg. No./Substance:
20830-81-3/Daunorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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