| Data requirements for risk assessment of furan in food. | |
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MedLine Citation:
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PMID: 17687705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Furan is an organic, volatile compound used in various chemical-manufacturing industries. Headspace gas chromatography is the analytical method of choice for obtaining reliable results on its occurrence. The presence of furan in some food items has been known since the late 1970s, but a US Food and Drug Administration (FDA) survey published in 2004 revealed the occurrence of furan in a broad variety of canned and jarred foods, including baby food, that undergo heat treatment. Furan is carcinogenic in rats and mice, showing a dose-dependent increase in hepatocellular adenomas and carcinomas. In rats, a dose-dependent increase of mononuclear leukaemia is evident and a very high incidence of cholangiocarcinomas of the liver, even at the lowest dose tested. There is evidence to indicate that furan-induced carcinogenicity is probably attributable to a genotoxic mechanism. However, chronic toxicity with secondary cell proliferation may indirectly amplify the tumour response. From the available data, there is a relative small difference between possible human exposure and the doses in experimental animals required to produce carcinogenic effects. However, reliable risk assessment requires further data on both toxicity and exposure. The European Food Safety Authority's (EFSA) Scientific Panel on Contaminants in the Food Chain (CONTAM) recommended these studies as part of a reliable risk assessment of furan in food. |
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Authors:
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C W Heppner; J R Schlatter |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Food additives and contaminants Volume: 24 Suppl 1 ISSN: 0265-203X ISO Abbreviation: Food Addit Contam Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-09 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500474 Medline TA: Food Addit Contam Country: England |
Other Details:
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Languages: eng Pagination: 114-21 Citation Subset: IM |
Affiliation:
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European Food Safety Authority, Unit on Contaminants, Parma, Parma, Italy. claudia.heppner@efsa.europa.eu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens, Environmental / analysis*, metabolism, toxicity DNA / drug effects, genetics Food Analysis / methods Food Contamination / analysis* Furans / analysis*, metabolism, toxicity Gas Chromatography-Mass Spectrometry / methods Humans Mice Mutagenesis / drug effects Neoplasms, Experimental / chemically induced Proto-Oncogenes / drug effects, genetics Rats Risk Assessment / methods |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens, Environmental; 0/Furans; 110-00-9/furan; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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