Document Detail

Data on the action spectrum for ultraviolet carcinogenesis.
MedLine Citation:
PMID:  1206737     Owner:  NLM     Status:  MEDLINE    
When 300, 310, or 320 nm monochromatic UV energy was given to albino mice in amounts proportional to its erythemal effectiveness, skin tumors developed on the exposed ears of the mice at approximately the same time and the same rate in all three groups. Thus the long wavelength limit of the carcinogenesis action spectrum paralleled that of the erythema action spectrum. No tumors were found in mice exposed to a 290-nm UV wavelength nor in those exposed to low dosages at 310 nm. All tumors observed in the group exposed to 300 nm were squamous cell carcinomas; 3 sarcomas and 5 squamous cell carcinomas were seen with the more penetrating doses of a 310-nm UV wavelength.
R G Freeman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  55     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-15     Completed Date:  1976-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1119-22     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Squamous Cell / etiology,  pathology
Dose-Response Relationship, Radiation
Neoplasms, Experimental / etiology*,  pathology
Neoplasms, Radiation-Induced*
Sarcoma, Experimental / etiology,  pathology
Ultraviolet Rays*

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