Document Detail


Dasatinib followed by second allogeneic hematopoietic stem cell transplantation for relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia after the first transplantation.
MedLine Citation:
PMID:  20824399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although allogeneic hematopoietic stem cell transplantation (HSCT) is an established treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), the prognosis of patients who relapse after allogeneic HSCT has been extremely poor. Dasatinib, a second-generation tyrosine kinase inhibitor, is a promising agent for the treatment of Ph-ALL. We report on a Ph-ALL patient who relapsed early after the first allogeneic HSCT, but achieved complete molecular remission with dasatinib alone. She remains in molecular remission 12 months after the second allogeneic HSCT. Dasatinib was generally well tolerated, but she developed myalgia, nausea and positive cytomegalovirus antigenemia. In addition, sudden-onset bloody diarrhea was observed 10 days after the second HSCT, which was possibly associated with the use of dasatinib in addition to the effect of the conditioning regimen and graft-versus-host disease. In conclusion, dasatinib is an effective agent for Ph-ALL with a poor prognosis, but may be associated with specific adverse events including opportunistic infection and gastrointestinal bleeding.
Authors:
Yoko Ishida; Kiriko Terasako; Kumi Oshima; Kana Sakamoto; Masahiro Ashizawa; Miki Sato; Misato Kikuchi; Shun-Ichi Kimura; Hideki Nakasone; Shinya Okuda; Shinichi Kako; Rie Yamazaki; Junji Nishida; Yoshinobu Kanda
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-09-08
Journal Detail:
Title:  International journal of hematology     Volume:  92     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-01-28     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-6     Citation Subset:  IM    
Affiliation:
Division of Hematology, Saitama Medical Center, Jichi Medical University, Omiya-ku, Saitama, Saitama, 330-8503, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Female
Graft vs Host Disease / pathology,  prevention & control
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*,  prevention & control*,  surgery
Protein Kinase Inhibitors / adverse effects,  therapeutic use*
Pyrimidines / adverse effects,  therapeutic use*
Recurrence
Remission Induction
Thiazoles / adverse effects,  therapeutic use*
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Protein Kinase Inhibitors; 0/Pyrimidines; 0/Thiazoles; RBZ1571X5H/dasatinib

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