| Darunavir, ritonavir, and etravirine pharmacokinetics in the cervicovaginal fluid and blood plasma of HIV-infected women. | |
| | |
MedLine Citation:
|
PMID: 21173188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report darunavir, ritonavir, and etravirine pharmacokinetics in cervicovaginal fluid and blood plasma for women from the Gender, Race and Clinical Experience (GRACE) study. Eight women received darunavir-ritonavir (600/100 mg) twice daily (b.i.d.); two also received etravirine (200 mg) b.i.d. Week 4 paired blood plasma and cervicovaginal fluid samples were collected over 12 h. Darunavir and etravirine cervicovaginal fluid exposures were higher than blood plasma exposures; ritonavir cervicovaginal fluid exposure was lower than blood plasma exposure. The high exposures of darunavir and etravirine in cervicovaginal fluid warrant further evaluation of these drugs for use in HIV-1 prevention. |
| | |
Authors:
|
Kristine Patterson; Steven Jennings; Ron Falcon; Joseph Mrus; Angela Kashuba |
Related Documents
:
|
15546258 - Chemokine levels in the jugular venous blood of migraine without aura patients during a... 2174298 - Flow cytometric detection of bovine viral diarrhea virus in peripheral blood leukocytes... 9774608 - Evaluation of a leukocyte stabilization reagent for use in the cytomegalovirus pp65 ant... 9394818 - The roles of complement receptors type 1 (cr1, cd35) and type 3 (cr3, cd11b/cd18) in th... 15166388 - Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarct... 7502968 - Electrocorticographic evaluation of iobitridol, a nonionic contrast medium, during sele... |
Publication Detail:
|
Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural Date: 2010-12-20 |
Journal Detail:
|
Title: Antimicrobial agents and chemotherapy Volume: 55 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-25 Completed Date: 2011-06-01 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
|
Languages: eng Pagination: 1120-2 Citation Subset: IM |
Affiliation:
|
University of North Carolina at Chapel Hill, AIDS Clinical Trials Unit, 130 Mason Farm Rd., CB 7215, Chapel Hill, NC 27599-7215, USA. Kristine_patterson@med.unc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female HIV Infections / blood, cerebrospinal fluid, drug therapy* Humans Middle Aged Pyridazines / blood*, cerebrospinal fluid*, pharmacokinetics Ritonavir / blood*, cerebrospinal fluid*, pharmacokinetics Sulfonamides / blood*, cerebrospinal fluid*, pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
|
AI077355/AI/NIAID NIH HHS; AI087065/AI/NIAID NIH HHS; AI50410/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Pyridazines; 0/Ritonavir; 0/Sulfonamides; 0/darunavir; 0/etravirine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidative stress induction of the MexXY multidrug efflux genes and promotion of aminoglycoside resis...
Next Document: Characterization of the Novel CMT Enzyme TEM-154.