| Darunavir is a good third-line antiretroviral agent for HIV-1 infected patients failing second-line protease inhibitor-based regimens in South India. | |
| | |
MedLine Citation:
|
PMID: 23045961 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Eleven protease mutations have been associated with reduced susceptibility to darunavir. In this study of 87 HIV-1-infected patients experiencing virologic failure to second-line regimens containing protease inhibitors boosted with ritonavir (viral load >1,000 HIV RNA copies/ml), we observed a low prevalence (3%) of ≥3 darunavir resistance associated mutations, indicating that this drug may be a good option for third-line antiretroviral therapy in southern India. |
| | |
Authors:
|
Shanmugam Saravanan; Vidya Madhavan; Balakrishnan Pachamuthu; Davey M Smith; Sunil Suhas Solomon; Sathasivam Sivamalar; Selvamuthu Poongulali; Nagalingeswaran Kumarasamy; Robert Schooley; Suniti Solomon; Rami Kantor |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
|
Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
YRG Centre for AIDS Research and Education (YRG CARE), Infectious Diseases Laboratory, Voluntary Health Services, Chennai, Tamilnadu, India, 600 113, +91 44 39106805, +91 44 22542939; saravanan@yrgcare.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with ...
Next Document: Magnetic Resonance Properties of Gd(III)-Bound Lipid-Coated Microbubbles and their Cavitation Fragme...