| Dark-rearing affects the development of benzodiazepine receptors in the central visual structures of rat brain. | |
| | |
MedLine Citation:
|
PMID: 3004666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The postnatal development of [3H]flunitrazepam binding to benzodiazepine receptors has been studied in the retina, lateral geniculate nucleus, superior colliculus, frontal cortex and visual cortex of the rat. In the frontal and visual cortices, binding reached the highest level at postnatal day 25 and then decreased slightly until adulthood. In the superior colliculus, the adult value of [3H]flunitrazepam binding is already reached at postnatal day 25, whereas in the retina the highest binding was found at postnatal day 50. The ontogeny of benzodiazepine binding sites in the visual regions does not essentially differ from that in other brain regions, suggesting that the appearance of [3H]flunitrazepam binding sites in the visual system is not correlated with the development of retinal function and the functional maturation of the visual system with regard to processing of light stimuli. Raising rats in complete darkness from birth until the age of 25 days resulted in significantly decreased binding levels in the lateral geniculate nucleus and in the superior colliculus by 29% and 17%, respectively, as compared to controls. [3H]Flunitrazepam binding in the other regions studied was not affected by dark-rearing. Presumably, the complete lack of visual experience interferes with the functional development of GABAergic mechanisms involved in the gating function of the subcortical visual centres for visual information transfer. |
| | |
Authors:
|
R Schliebs; T Rothe; V Bigl |
Related Documents
:
|
7689736 - Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of gabaa rec... 6319606 - Ivermectin interactions with benzodiazepine receptors in rat cortex and cerebellum in v... 2845996 - In vivo determination of the profile of benzodiazepine ligands by comparing the inhibit... 1332016 - Kava pyrones and resin: studies on gabaa, gabab and benzodiazepine binding sites in rod... 4065696 - Does the reticulin binding property of cereal proteins demonstrable in vitro have patho... 3360216 - Autoradiographic evidence for insulin and insulin-like growth factor binding to early m... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Brain research Volume: 389 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1986 Jan |
Date Detail:
|
Created Date: 1986-04-07 Completed Date: 1986-04-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 179-85 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Brain Chemistry* Cerebral Cortex / metabolism*, physiology Darkness* Female Flunitrazepam / metabolism Geniculate Bodies / metabolism Lighting Male Photic Stimulation Rats Rats, Inbred Strains Receptors, GABA-A / analysis, physiology* Retina / metabolism Superior Colliculi / metabolism Visual Pathways / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, GABA-A; 1622-62-4/Flunitrazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The ontogeny of specific prolactin binding sites in the rat choroid plexus.
Next Document: Autoradiographic study of beta 1-adrenergic receptor development in the mouse forebrain.