Document Detail


Daptomycin for the treatment of gram-positive infections after cardiac surgery.
MedLine Citation:
PMID:  23149592     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND AND METHOD: Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. CONCLUSION: Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus.
Authors:
B Luchting; F Weis; J Heyn; A Beiras-Fernandez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Medizinische Klinik, Intensivmedizin und Notfallmedizin     Volume:  -     ISSN:  2193-6226     ISO Abbreviation:  Med Klin Intensivmed Notfmed     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101575086     Medline TA:  Med Klin Intensivmed Notfmed     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Klinik für Anaesthesiologie, Klinikum der Universität München - Campus Großhadern, München, Deutschland.
Vernacular Title:
Daptomycin zur Behandlung grampositiver Infektionen nach herzchirurgischen Eingriffen.
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