| Daptomycin for the treatment of gram-positive infections after cardiac surgery. | |
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MedLine Citation:
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PMID: 23149592 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND METHOD: Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. CONCLUSION: Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus. |
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Authors:
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B Luchting; F Weis; J Heyn; A Beiras-Fernandez |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Medizinische Klinik, Intensivmedizin und Notfallmedizin Volume: - ISSN: 2193-6226 ISO Abbreviation: Med Klin Intensivmed Notfmed Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101575086 Medline TA: Med Klin Intensivmed Notfmed Country: - |
Other Details:
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Languages: GER Pagination: - Citation Subset: - |
Affiliation:
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Klinik für Anaesthesiologie, Klinikum der Universität München - Campus Großhadern, München, Deutschland. |
Vernacular Title:
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Daptomycin zur Behandlung grampositiver Infektionen nach herzchirurgischen Eingriffen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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