| Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis. | |
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MedLine Citation:
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PMID: 23089753 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In a patient with mitral-aortic, native valve, Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In case of aortic, porcine valve, Staphylococcus epidermidis endocarditis, daptomycin concentration was 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase. |
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Authors:
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Carlo Tascini; Antonello Di Paolo; Roberta Poletti; Sarah Flammini; Michele Emdin; Ilaria Ciullo; Enrico Tagliaferri; Annette Moter; Francesco Menichetti |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-22 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: - ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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U.O. C. Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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