Document Detail

Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis.
MedLine Citation:
PMID:  23089753     Owner:  NLM     Status:  MEDLINE    
In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.
Carlo Tascini; Antonello Di Paolo; Roberta Poletti; Sarah Flammini; Michele Emdin; Ilaria Ciullo; Enrico Tagliaferri; Annette Moter; Francesco Menichetti
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-10-22
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  57     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  2013-06-10     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-2     Citation Subset:  IM    
U.O.C. Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
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MeSH Terms
Anti-Bacterial Agents / pharmacokinetics*,  pharmacology,  therapeutic use
Aortic Valve / pathology,  surgery
Bioprosthesis / microbiology*
Daptomycin / pharmacokinetics*,  pharmacology,  therapeutic use
Endocarditis, Bacterial / drug therapy*,  microbiology
Heart Valve Prosthesis / microbiology*
Middle Aged
Mitral Valve / pathology,  surgery
Staphylococcal Infections / drug therapy*,  microbiology
Staphylococcus / drug effects,  growth & development
Staphylococcus epidermidis / drug effects,  growth & development
Reg. No./Substance:
0/Anti-Bacterial Agents; 103060-53-3/Daptomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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