Document Detail

Dapsone resistant leprosy, the western Kenya experience.
MedLine Citation:
PMID:  4035777     Owner:  NLM     Status:  MEDLINE    
41 patients out of 804 registered lepromatous (LL) and borderline lepromatous (BL) patients were studied for possible dapsone resistance by series of biopsy specimens, skin smears and clinical examination. These patients were drawn from a pool of 4384 registered leprosy patients in the west Kenya Leprosy Control Project area. Six out of fourty one cases (14.6%) were confirmed as dapsone resistant by series of biopsy specimens taken when patients were on supervised dapsone therapy; 11 patients (26.8%) were suspected to be resistant and 24 patients (58.6%) responded well to dapsone therapy. All the confirmed cases were lepromatous leprosy cases. We therefore found that there is dapsone resistance here with a maximal prevalence rate of 7 per 1000 in all lepromatous cases and 14.6% in clinically suspicious cases.
P A Orege; D M Owili
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tropical and geographical medicine     Volume:  37     ISSN:  0041-3232     ISO Abbreviation:  Trop Geogr Med     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-09-30     Completed Date:  1985-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376231     Medline TA:  Trop Geogr Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM    
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MeSH Terms
Dapsone / therapeutic use*
Drug Resistance, Microbial
Leprosy / drug therapy*
Reg. No./Substance:

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