Document Detail


Dapoxetine for premature ejaculation.
MedLine Citation:
PMID:  21085116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Premature ejaculation (PE) is the most common form of male sexual dysfunction, with an estimated worldwide prevalence of 20–30%.1 Although PE is not life threatening, it has significant impact on quality of life. The fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)defines PE as “persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it” that “causes marked distress or interpersonal difficulty” and “is not due exclusively to the direct effects of a substance.”2 The International Society for Sexual Medicine, which recently modified the definition to include the threshold ejaculatory latency time, defines PEas “male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior to or within 1 min of vaginal penetration; the inability to delay ejaculation on all or nearly all vaginal penetrations; and negative personal consequences such as distress, bother, frustration, and/or the avoidance of sexual intimacy.”3 The lack of ejaculatory control is consistent among all clinical definitions of PE and is a highly sensitive predictor of the condition.
Authors:
A M Feige; M R Pinsky; W J G Hellstrom
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Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  89     ISSN:  1532-6535     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzylamines / adverse effects,  pharmacokinetics,  therapeutic use*
Ejaculation / drug effects*,  physiology
Humans
Male
Naphthalenes / adverse effects,  pharmacokinetics,  therapeutic use*
Protein Isoforms / physiology
Receptors, Serotonin / physiology
Serotonin Uptake Inhibitors / adverse effects,  pharmacokinetics,  therapeutic use*
Sexual Dysfunction, Physiological / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Benzylamines; 0/Naphthalenes; 0/Protein Isoforms; 0/Receptors, Serotonin; 0/Serotonin Uptake Inhibitors; 119356-77-3/dapoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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