Document Detail

Dapiprazole for patients with night haloes after excimer keratectomy.
MedLine Citation:
PMID:  8871165     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Haloes causing difficulties during the night driving are one of the common complications of photorefractive keratectomy (PRK). The presumed reason for this phenomenon is the different refraction of light through the treated and untreated areas of the cornea. Its magnitude is proportional to the ratio between the treated area and pupil size. At nighttime, when the pupil dilates, rays from treated and untreated areas of the cornea reach the retina at different foci and produce haloes. We investigated whether dapiprazole, a miotic alpha-blocker drug, would be helpful in reducing night haloes in patients after PRK. METHODS: Twenty-four patients who complained of night haloes after PRK participated in our study. All were given dapiprazole 0.5% before night driving. Change in pupil size was recorded, and all patients completed a questionnaire on changes in the severity of haloes after instillation of dapiprazole. RESULTS: Improvement was described as very significant in five patients, moderate in ten and slight in seven. There was no improvement in two patients. The only side effect was slight irritation, which resolved within 1 h. CONCLUSION: Our results demonstrate that dapiprazole improves the subjective discomfort caused by night haloes in post-PRK patients.
Y Alster; A Loewenstein; T Baumwald; I Lipshits; M Lazar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  234 Suppl 1     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-16     Completed Date:  1997-01-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  S139-41     Citation Subset:  IM    
Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
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MeSH Terms
Adrenergic alpha-Antagonists / therapeutic use*
Automobile Driving
Lasers, Excimer
Middle Aged
Ophthalmic Solutions
Photorefractive Keratectomy / adverse effects*
Pilot Projects
Pupil / drug effects
Treatment Outcome
Triazoles / therapeutic use*
Vision Disorders / drug therapy*,  etiology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Ophthalmic Solutions; 0/Piperazines; 0/Triazoles; 72822-12-9/dapiprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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