Document Detail


The Danish Twin Registry: 127 birth cohorts of twins.
MedLine Citation:
PMID:  12537858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Danish Twin Registry is the oldest national twin register in the world, initiated in 1954 by ascertainment of twins born from 1870 to 1910. During a number of studies birth cohorts have been added to the register, and by the recent addition of birth cohorts from 1931 to 1952 the Registry now comprizes 127 birth cohorts of twins from 1870 to 1996, with a total of more than 65,000 twin pairs included. In all cohorts the ascertainment has been population-based and independent of the traits studied, although different procedures of ascertainment have been employed. In the oldest cohorts only twin pairs with both twins surviving to age 6 have been included while from 1931 all ascertained twins are included. The completeness of the ascertainment after adjustment for infant mortality is high, with approximately 90% ascertained up to 1968, and complete ascertainment of all liveborn twin pairs since 1968. The Danish Twin Registry is used as a source for large studies on genetic influence on aging and age-related health problems, normal variation in clinical parameters associated with the metabolic syndrome and cardiovascular diseases, and clinical studies of specific diseases. The combination of survey data with data obtained by linkage to national health related registers enables follow-up studies both of the general twin population and of twins from clinical studies.
Authors:
Axel Skytthe; Kirsten Kyvik; Niels V Holm; James W Vaupel; Kaare Christensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Twin research : the official journal of the International Society for Twin Studies     Volume:  5     ISSN:  1369-0523     ISO Abbreviation:  Twin Res     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815819     Medline TA:  Twin Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Affiliation:
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark. askytthe@health.sdu.dk
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MeSH Terms
Descriptor/Qualifier:
Aging / genetics
Cardiovascular Diseases / epidemiology,  genetics
Child
Child, Preschool
Cohort Studies*
Data Collection
Denmark / epidemiology
Diseases in Twins / epidemiology,  genetics
Humans
Infant
Infant Mortality
Infant, Newborn
Population Surveillance / methods*
Registries* / statistics & numerical data
Twin Studies as Topic / methods*,  statistics & numerical data
Twins* / genetics,  statistics & numerical data
Grant Support
ID/Acronym/Agency:
P01-AG08761/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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