| Danazol-induced biochemical changes in the rat ovary. | |
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MedLine Citation:
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PMID: 10225053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effect of varying doses of danazol, a synthetic steroid derivative of 17 alpha-ethinyl testosterone has been observed on the biochemistry of the rat ovary. Biochemically total proteins decreased and total lipids increased with the danazol treatment. Triglycerides, the stored form of lipids formed the major components of lipids in the treated ovaries. The amount of phospholipids, glycolipids, cholesterol and free fatty acids decreased in the ovaries with increased danazol treatment. The functional significance of these changes have been discussed with ovarian physiology especially in relation to follicular growth and atresia. |
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Authors:
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G K Sangha; N Chopra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 42 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: INDIA |
Other Details:
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Languages: eng Pagination: 252-8 Citation Subset: IM |
Affiliation:
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Department of Zoology, College of Basic Sciences & Humanities, Punjab Agricultural University, Ludhiana. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Danazol / pharmacology* Dose-Response Relationship, Drug Estrogen Antagonists / pharmacology* Fatty Acids, Nonesterified / metabolism Female Glycolipids / metabolism Injections, Subcutaneous Ovary / drug effects*, metabolism*, physiology Phospholipids / metabolism Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Antagonists; 0/Fatty Acids, Nonesterified; 0/Glycolipids; 0/Phospholipids; 17230-88-5/Danazol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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