Document Detail


Danazol in the treatment of myelodysplastic syndromes.
MedLine Citation:
PMID:  3319676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
20 patients with myelodysplastic syndromes (MDS) were treated with danazol, 800 mg daily in 4 divided doses. 18 patients were evaluable for response. 3 patients (17%), whose principal problem was anemia, responded to treatment, but only with an increase in platelet count. Responses were short-lived and lacked clinical significance. No patients with anemia or leukopenia responded to treatment and none of the 7 patients with a platelet count less than 30 x 10(9)/l responded. Danazol appears to have limited clinical utility in the treatment of MDS. However, occasional patients with thrombocytopenia may benefit.
Authors:
A C Buzaid; H S Garewal; S M Lippman; B G Durie; S B Katakkar; B R Greenberg
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  39     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-20     Completed Date:  1988-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
Affiliation:
Arizona Cancer Center, Tucson.
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Danazol / adverse effects,  therapeutic use*
Female
Humans
Male
Myelodysplastic Syndromes / drug therapy*
Pregnadienes / therapeutic use*
Chemical
Reg. No./Substance:
0/Pregnadienes; 17230-88-5/Danazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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