Document Detail

Danazol in the treatment of endometriosis: analysis of 100 cases with a 4-year follow-up.
MedLine Citation:
PMID:  7084496     Owner:  NLM     Status:  MEDLINE    
A prospective study to evaluate the efficacy of danazol in the treatment of endometriosis was initiated in 1976. One hundred patients with endometriosis, as demonstrated by laparoscopy, were entered into the study. The mean length of patient follow-up was 49 months. All patients were treated with 800 mg of danazol per day. The mean duration of danazol therapy was 17.3 weeks. Eighty-nine percent of the patients reported symptomatic improvement, and 94% were improved, as demonstrated by repeat laparoscopy or laparatomy. After completing a course of danazol therapy, 57% of the patients underwent conservative laparotomy for fertility enhancement, pain control, or ovarian masses. Two patients underwent total abdominal hysterectomy-bilateral salpingo-oophorectomy for advanced disease poorly responsive to danazol therapy. In those patients desiring fertility (56), there were 38 pregnancies in 26 women, for an overall fertility rate of 46%. The overall recurrence rate was 33%, as determined by symptoms and physical findings. Significant side effects from danazol were reported by 85% of the patients. The major side effects were weight gain, edema, decrease in breast size, oily skin, hirsutism, and deepening of the voice. Only one patient discontinued danazol therapy due to side effects. Clinical tissues concerning the use of danazol with or without surgery and the miscarriage rate following danazol therapy are discussed.
R L Barbieri; S Evans; R W Kistner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  37     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-08-14     Completed Date:  1982-08-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-46     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous
Body Weight
Danazol / adverse effects,  therapeutic use*
Edema / etiology
Endometriosis / drug therapy*
Follow-Up Studies
Hirsutism / etiology
Pregnadienes / therapeutic use*
Prospective Studies
Reg. No./Substance:
0/Pregnadienes; 17230-88-5/Danazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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