Document Detail


Danaparoid: an antithrombotic agent without major impact on triglyceride hydrolysis capacity in humans.
MedLine Citation:
PMID:  9279289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Heparin is a widely used antithrombotic drug. Besides its anticoagulant properties, it also has a marked influence on lipid metabolism, by decreasing serum lipolytic activity due to lipase depletion from vascular sites and stores. Especially in haemodialysis patients who receive heparin during every dialysis session, and in hypertriglyceridaemic patients, decreasing lipolytic activity can lead to the accumulation of triglyceride-rich lipoproteins, which are atherogenic. Replacement of heparin by an antithrombotic drug with less lipase releasing activity might reduce this risk. DESIGN: We tested danaparoid, a new antithrombotic drug, and compared its ability to displace biotinylated heparan sulphate from lipoprotein lipase in vitro with heparin. Furthermore we compared the in vivo lipase releasing activity. RESULTS: Danaparoid displaced significantly less biotinylated heparan sulphate from triglyceride-rich lipoprotein-lipoprotein lipase complexes in vitro than heparin. Intravenous injection of danaparoid released less than 20% (P < 0.05) of the lipolytic activity released by an equivalent anticoagulant dose of heparin. CONCLUSION: Danaparoid is the drug of choice during the antithrombotic therapy of hypertriglyceridaemic or haemodialysis patients.
Authors:
H H van Barlingen; A van Beek; D W Erkelens; T W de Bruin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  242     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital, Utrecht University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / pharmacology
Chondroitin Sulfates / pharmacology*
Dermatan Sulfate / pharmacology*
Drug Combinations
Female
Heparin / pharmacology
Heparinoids / pharmacology*
Heparitin Sulfate / pharmacology*
Humans
Hydrolysis / drug effects
Hypertriglyceridemia / drug therapy
Lipoprotein Lipase / metabolism
Reference Values
Renal Dialysis
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Drug Combinations; 0/Heparinoids; 0/Triglycerides; 24967-94-0/Dermatan Sulfate; 83513-48-8/danaproid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate; EC 3.1.1.34/Lipoprotein Lipase
Comments/Corrections
Comment In:
J Intern Med. 1998 Aug;244(2):184   [PMID:  10095808 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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