| Danaparoid: an antithrombotic agent without major impact on triglyceride hydrolysis capacity in humans. | |
| | |
MedLine Citation:
|
PMID: 9279289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Heparin is a widely used antithrombotic drug. Besides its anticoagulant properties, it also has a marked influence on lipid metabolism, by decreasing serum lipolytic activity due to lipase depletion from vascular sites and stores. Especially in haemodialysis patients who receive heparin during every dialysis session, and in hypertriglyceridaemic patients, decreasing lipolytic activity can lead to the accumulation of triglyceride-rich lipoproteins, which are atherogenic. Replacement of heparin by an antithrombotic drug with less lipase releasing activity might reduce this risk. DESIGN: We tested danaparoid, a new antithrombotic drug, and compared its ability to displace biotinylated heparan sulphate from lipoprotein lipase in vitro with heparin. Furthermore we compared the in vivo lipase releasing activity. RESULTS: Danaparoid displaced significantly less biotinylated heparan sulphate from triglyceride-rich lipoprotein-lipoprotein lipase complexes in vitro than heparin. Intravenous injection of danaparoid released less than 20% (P < 0.05) of the lipolytic activity released by an equivalent anticoagulant dose of heparin. CONCLUSION: Danaparoid is the drug of choice during the antithrombotic therapy of hypertriglyceridaemic or haemodialysis patients. |
| | |
Authors:
|
H H van Barlingen; A van Beek; D W Erkelens; T W de Bruin |
Related Documents
:
|
19632199 - Heparin-induced circular dichroism of chloroquine. 16824849 - Provisional glycoprotein iib/iiia blockade in a randomized investigation of bivalirudin... 17201079 - Delayed thrombin generation is not associated with fibrinopeptide formation during prol... 16123909 - Discovery of ximelagatran in an historical perspective. 16268469 - Drug interactions and risk of acute bleeding leading to hospitalisation or death in pat... 2905759 - Haematological adverse effects of histamine h2-receptor antagonists. 23201049 - Spatially discrete thermal drawing of biodegradable microneedles for vascular drug deli... 7295239 - The use of imidocarb diproprionate for the treatment of theileria sergenti infections o... 11772829 - Bupivacaine-induced qrs prolongation is enhanced by lidocaine and by phenytoin in rabbi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of internal medicine Volume: 242 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1997 Aug |
Date Detail:
|
Created Date: 1997-09-11 Completed Date: 1997-09-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University Hospital, Utrecht University, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anticoagulants / pharmacology Chondroitin Sulfates / pharmacology* Dermatan Sulfate / pharmacology* Drug Combinations Female Heparin / pharmacology Heparinoids / pharmacology* Heparitin Sulfate / pharmacology* Humans Hydrolysis / drug effects Hypertriglyceridemia / drug therapy Lipoprotein Lipase / metabolism Reference Values Renal Dialysis Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Anticoagulants; 0/Drug Combinations; 0/Heparinoids; 0/Triglycerides; 24967-94-0/Dermatan Sulfate; 83513-48-8/danaproid; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates; 9050-30-0/Heparitin Sulfate; EC 3.1.1.34/Lipoprotein Lipase |
| Comments/Corrections | |
Comment In:
|
J Intern Med. 1998 Aug;244(2):184
[PMID:
10095808
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reproducibility of on-line vectorcardiography measurements in patients with and without acute ischae...
Next Document: Health, health care utilization and living conditions in foreign-born diabetic patients in southern ...