Document Detail


Damping of intraocular pressure fluctuations.
MedLine Citation:
PMID:  22394411     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:   There is increasing evidence that relatively rapid spikes in intraocular pressure (IOP) may contribute to axonal damage in glaucoma. The present study seeks to quantify the ability of a compressible damping element (a simple air bubble) to reduce intraocular IOP fluctuations induced by a known change in intraocular fluid volume. Methods:  A mathematical model describing the damping of IOP increases for a given infusion volume was developed and compared with experimental data obtained from isolated pig eyes. A damping element (100 µL to 2 mL of air) was added to the system and the effect on the induced IOP change for a given infusion volume was assessed. Results:  The introduction of the damping element reduced the IOP change in a volume dependent manner consistent with the mathematical modelling. The maximum bubble size tested (2 mL) dampened the IOP change by an average of 63.5 + 8.7 % at a baseline pressure close to 20 mmHg. Close agreement was seen between the mathematical model and the experimental data. Conclusion:  Mathematical modelling and experiments in isolated pig eyes demonstrated that the addition of a damping element in the form of a compressible air bubble is capable of significantly reducing induced IOP spikes. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Authors:
Stephen J Cringle; Dao-Yi Yu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-7
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  -     ISSN:  1442-9071     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation:
Centre for Ophthalmology and Visual Science and the ARC Centre of Excellence in Vision Science, The University of Western Australia, Perth, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pv12, A 6-Cys antigen of Plasmodium vivax, is localized to the merozoite rhoptry.
Next Document:  Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute...