| Damping index of Doppler hepatic vein waveform to assess the severity of portal hypertension and response to propranolol in liver cirrhosis: a prospective nonrandomized study. | |
| | |
MedLine Citation:
|
PMID: 17845539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Alterations in the Doppler hepatic vein (HV) waveform are associated with cirrhosis and portal hypertension. We prospectively evaluated the correlation between the extent of abnormal Doppler HV waveforms expressed as damping index (DI) and the hepatic venous pressure gradient (HVPG) and response to propranolol in patients with cirrhosis. MATERIAL AND METHODS: In 76 patients with cirrhosis (69 men and seven women), both DI of Doppler HV waveform and HVPG were measured, and the relationship between them was analysed. DI was calculated by the minimum velocity/maximum velocity of the HV waveform. An HVPG>12 mmHg was defined as severe portal hypertension. In a subgroup of 19 patients receiving propranolol, changes in both DI and HVPG were evaluated after propranolol administration for 3 months. One author (S. K. B.) performed all DI of Doppler HV waveform studies. RESULTS: Abnormal HV waveforms were seen in 66 of 76 patients (86.8%). DI significantly correlated with the grade of HVPG, i.e. with higher HVPG increased DI was observed (P<0.01). By logistic regression analysis, DI>0.6 was significantly more likely to be severe portal hypertension (odds ratio: 14.19, 95% confidence interval: 4.07-49.55). Receiver-operating characteristic curve according to the value of 0.6 of DI showed a sensitivity of 75.9% and a specificity of 81.8% for the presence of severe portal hypertension. In 19 patients of the propranolol subgroup, change of DI following propranolol treatment also significantly correlated with that of HVPG (P<0.01). CONCLUSIONS: Damping index of the HV waveform by Doppler ultrasonography might be a non-invasive supplementary tool in evaluating the severity of portal hypertension and in responding to propranolol in patients with liver cirrhosis. |
| | |
Authors:
|
Moon Young Kim; Soon Koo Baik; Dong Hun Park; Dae Wook Lim; Jae Woo Kim; Hyun Soo Kim; Sang Ok Kwon; Young Ju Kim; Sei Jin Chang; Samuel S Lee |
Related Documents
:
|
20810049 - Effect of carvedilol on portal pressure estimated by hepatic vein doppler ultrasound wa... 3047519 - The effect of glipizide on extraction of insulin by the human cirrhotic and noncirrhoti... 2161609 - Hepatic hydrothorax: report of two cases. 8781329 - Transjugular intrahepatic portosystemic shunt for the management of severe venoocclusiv... 10776439 - The lidocaine (megx) test as an index of hepatic function: its clinical usefulness in l... 6496849 - Rhythm abnormalities of the biliary and pancreatic sphincters: diagnosis by endoscopic ... 1701889 - The effects of equitation (horseback riding) on a motion responsive dddr pacemaker. 8410749 - Personality characteristics and serum ige level in patients with atopic dermatitis. 12929189 - Clinical spectrum of muscle weakness in human west nile virus infection. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Liver international : official journal of the International Association for the Study of the Liver Volume: 27 ISSN: 1478-3223 ISO Abbreviation: Liver Int. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-11 Completed Date: 2007-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101160857 Medline TA: Liver Int Country: England |
Other Details:
|
Languages: eng Pagination: 1103-10 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Institute of Lifelong Health, Wonju College of Medicine, Yonsei University, Wonju, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antihypertensive Agents / pharmacology, therapeutic use* Female Hepatic Veins / drug effects, physiopathology, ultrasonography* Humans Hypertension, Portal / drug therapy*, etiology, physiopathology, ultrasonography* Linear Models Liver Cirrhosis / complications*, drug therapy, physiopathology, ultrasonography Male Middle Aged Odds Ratio Predictive Value of Tests Propranolol / pharmacology, therapeutic use* Prospective Studies ROC Curve Reproducibility of Results Risk Assessment Sensitivity and Specificity Severity of Illness Index Treatment Outcome Ultrasonography, Doppler, Duplex* Venous Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidence of psychiatric side effects during pegylated interferon- alpha retreatment in nonresponder...
Next Document: Efficacy of interferon alpha-2b induction therapy before retreatment for chronic hepatitis C.