| Dampening of Blood-Flow Pulsatility along the Carotid Siphon: Does Form Follow Function? | |
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MedLine Citation:
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PMID: 21474624 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The tortuous distal part of the ICA may have an attenuating effect on pulsatile arterial flow. We investigated local arterial blood flow patterns in the ICA proximal and distal to the carotid siphon to detect quantitative waveform changes. MATERIALS AND METHODS: Arterial flow patterns were analyzed by using flow-sensitized 4D PC MR imaging (time-resolved 3D PCMR) at 3T in 17 healthy volunteers. Time-resolved blood flow velocities were extracted from the source data at the C4 and C7 segments of the ICA. PI, RI, and PA were calculated by using time-resolved flow volume. A linear mixed-effects model was applied to compare values at C4 and C7. Furthermore, 3D blood flow visualization was performed for all 34 ICAs. RESULTS: PI, RI, and PA were significantly lower at the distal C7 segment compared with the proximal C4 segment of the ICA (P < .0001). Helical flow patterns were observed in 5 ICAs of 4 subjects. CONCLUSIONS: Arterial flow patterns showed a significant reduction in PI, RI, and PA when compared distal to proximal to the carotid siphon. The observed attenuation of flow pulsatility is most likely related to the contorted shape of the distal ICA and may bear a protective effect for downstream cerebral vasculature. |
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Authors:
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T Schubert; F Santini; A F Stalder; J Bock; S Meckel; L Bonati; M Markl; S Wetzel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-7 |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: - ISSN: 1936-959X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Radiology and Neurology, University Hospital Basle, Basle, Switzerland; Department of Radiology, Medical Physics, University Hospital Basle, Basle, Switzerland; Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany; Department of Neuroradiology, University Hospital Freiburg, Freiburg, Germany; Department of Neuroradiology, Swiss Neuro Institute Zurich, Hirslanden Clinic, Zurich, Switzerland; and Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China. |
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