Document Detail


Dammarane-type saponins from Gynostemma pentaphyllum.
MedLine Citation:
PMID:  20382401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dammarane-type saponins, gypenosides VN1-VN7 (1-7), were isolated from the total saponin extract of Gynostemma pentaphyllum aerial parts, with their structures elucidated on the basis of spectroscopic and chemical methods. These compounds showed moderate cytotoxic activity against four human cancer cell lines, A549 (lung), HT-29 (colon), MCF-7 (breast), and SK-OV-3 (ovary), with IC(50) values ranging from 19.6+/-1.1 to 43.1+/-1.0 microM. Regarding the HL-60 (acute promyelocytic leukemia) cell line, compounds 1, 5, and 6 showed weakly active with IC(50) values of 62.8+/-1.9, 72.6+/-3.6, and 82.4+/-3.2 nM, respectively, while 2, 3, 4, and 7 were less active with IC(50) values>100 microM.
Authors:
Pham Thanh Ky; Pham Thanh Huong; Than Kieu My; Pham Tuan Anh; Phan Van Kiem; Chau Van Minh; Nguyen Xuan Cuong; Nguyen Phuong Thao; Nguyen Xuan Nhiem; Jae-Hee Hyun; Hee-Kyoung Kang; Young Ho Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-09
Journal Detail:
Title:  Phytochemistry     Volume:  71     ISSN:  1873-3700     ISO Abbreviation:  Phytochemistry     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  994-1001     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Hanoi University of Pharmacy, 17 Le Thanh Tong, Hanoi, Vietnam.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology
Drug Screening Assays, Antitumor
Female
Gynostemma / chemistry*
HL-60 Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Saponins / chemistry,  isolation & purification*,  pharmacology
Triterpenes / chemistry,  isolation & purification*,  pharmacology
Vietnam
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Triterpenes; 545-22-2/dammarane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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