Document Detail

Dammarane-type saponins from the flower buds of Panax ginseng and their intracellular radical scavenging capacity.
MedLine Citation:
PMID:  20030409     Owner:  NLM     Status:  MEDLINE    
Korean ginseng (Panax ginseng C.A. Meyer) has been extensively used as a functional food for thousands of years. This study with the aim to evaluate the potential of P. ginseng flower components as a functional food with medicinal properties resulted in the identification of three new dammarane-type saponins, named floralginsenosides Ka-Kc (1-3), along with seventeen known ones (4-20). Their structures were elucidated on the basis of chemical and spectroscopic methods, and their antioxidant activities were evaluated by the intracellular ROS radical scavenging DCF-DA assay. Among them, floralginsenoside Ka (1) displayed potent scavenging activity with the inhibition value of 64% at 10 microM; and ginsenoside Rb(1) (13), floralginsenoside Kc (3), floralginsenoside Kb (2), vinaginsenoside R(9) (11), majoroside F(1) (12), ginsenoside I (17), and ginsenoside II (18) showed moderate scavenging capacity with the inhibition rate of 28, 33, 35, 35, 35, 38, and 38% at 10 microM, respectively. These results warrant further studies concerning the potential of saponin extracts of P. ginseng flowers for functional foods.
Nguyen Huu Tung; Gyu Yong Song; Nguyen Xuan Nhiem; Yan Ding; Bui Huu Tai; Long Guo Jin; Chae-Moon Lim; Jin Won Hyun; Chun Jung Park; Hee Kyoung Kang; Young Ho Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  58     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-74     Citation Subset:  IM    
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
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MeSH Terms
Cell Line
Drugs, Chinese Herbal / chemistry*,  pharmacology
Flowers / chemistry
Free Radical Scavengers / chemistry*,  pharmacology
Intracellular Space / chemistry*,  drug effects,  metabolism
Panax / chemistry*
Reactive Oxygen Species / chemistry,  metabolism
Saponins / chemistry*,  pharmacology
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/Saponins

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