| Damaging effects of intense repetitive treadmill running on murine intestinal musculature. | |
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MedLine Citation:
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PMID: 18309097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several gastrointestinal symptoms associated with prolonged intense exercise (IE) have been reported, although the mechanisms underlying its effects on the intestine remain poorly understood. The aim of the present study was to investigate whether IE may induce oxidative stress in the intestine, as well as its possible relationship with intestinal signaling impairments, leading to contractile disturbances. C57BL/6 mice were submitted to 4 days (EX.4D) and 10 days (EX.10D) of IE. The daily exercise session consisted of a running session until exhaustion, with the treadmill speed set at 85% of each animal's maximum velocity. The decrease in exhaustion time was exponential, and the reduction in the maximum velocity, as assessed by an incremental test, was higher in EX.4D than in EX.10D animals. The ileum mucosa layer was partially destroyed after 4 days of IE, where 37% and 11% muscle layer atrophies were observed in EX.4D and EX.10D animals, respectively. Ileum contractility was significantly impaired in the EX.4D animal group, with reduced efficacy for carbachol, bradykinin, and KCl signaling associated with a decrease in lipid peroxidation and with no alteration of protein oxidation. Intestinal myocytes from EX.10D animals displayed areas containing structurally disorganized mitochondria, which were associated with increased levels of protein oxidation, without alteration of contractility, except for a reduction in the potency of bradykinin signaling. Finally, no clear relationship between ileum contractility and oxidative stress was shown. Together, these results argue in favor of significant functional, biochemical, and morphological disturbances caused by exercise, thus demonstrating that intestinal tissue is very sensitive to exercise. |
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Authors:
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Eloi F Rosa; Edna Freymüller; Silvia S M Ihara; Jeannine Aboulafia; Viviane L A Nouailhetas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-28 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 104 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-02 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1410-7 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Universidade Federal de São Paulo/Escola Paulista de Medicina, Rua Botucatu 862, 7o andar,São Paulo, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology Bradykinin / pharmacology Carbachol / pharmacology Ileum / pathology, physiology Intestines / injuries*, pathology, physiopathology Isometric Contraction / physiology Lactic Acid / blood Lipid Peroxidation / physiology Male Mice Mice, Inbred C57BL Muscarinic Agonists / pharmacology Muscle Contraction / physiology Muscle, Smooth / pathology* N-Methylaspartate / metabolism Oxidative Stress / physiology Physical Conditioning, Animal / physiology Potassium Chloride / pharmacology Protein Carbonylation / physiology Running / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Muscarinic Agonists; 50-21-5/Lactic Acid; 51-83-2/Carbachol; 58-82-2/Bradykinin; 6384-92-5/N-Methylaspartate; 7447-40-7/Potassium Chloride |
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