| Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice. | |
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MedLine Citation:
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PMID: 17676428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the alteration of oligodendrocytes in comparison with that of astrocytes and microglia in the mouse striatum after MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropridine) treatment under the same conditions using Western blot analysis and Immunohistochemistry. In our Western blot analysis, four administrations of MPTP at 2-h intervals to mice produced the remarkable loss of TH (tyrosine hydroxylase) protein levels in the striatum after 3 and 7 days. In contrast, GFAP (glial fibrillary acidic protein) and Iba-1 protein in the striatum showed a significant increase of GFAP and Iba-1 protein levels 3 and 7 days after MPTP treatment. On the other hand, the levels of CNPase (2', 3'-cyclic nucleotide 3'-phosphodiesterase) protein were decreased significantly in the striatum 3 and 7 days after MPTP treatment. In our immunohistochemical study, a significant decrease in the area of expression of CNPase-positive profiles was observed in the striatum 3 and 7 days after MPTP treatment. These results demonstrate that oligodendrocytes in the striatum are damaged after MPTP treatment. Thus our present findings provide valuable information for the pathogenesis of Parkinson's disease. |
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Authors:
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S Takagi; N Hayakawa; H Kimoto; H Kato; T Araki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-06 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 114 ISSN: 0300-9564 ISO Abbreviation: J Neural Transm Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 1553-7 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2',3'-Cyclic-Nucleotide Phosphodiesterases
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drug effects,
metabolism Animals Astrocytes / drug effects, pathology Blotting, Western Calcium-Binding Proteins / drug effects, metabolism Corpus Striatum / drug effects*, metabolism, pathology* Glial Fibrillary Acidic Protein / drug effects, metabolism Immunohistochemistry MPTP Poisoning / metabolism, pathology* Male Mice Mice, Inbred C57BL Microglia / drug effects, pathology Oligodendroglia / drug effects*, metabolism, pathology* Tyrosine 3-Monooxygenase / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Aif1 protein, mouse; 0/Calcium-Binding Proteins; 0/Glial Fibrillary Acidic Protein; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 3.1.4.-/2',3'-Cyclic-Nucleotide Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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