| Damage to lung epithelial cells and lining fluid antioxidant defense by humic acid. | |
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MedLine Citation:
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PMID: 21783895 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Humic acid causes diseases including lung emphysema and fibrosis. Emerging evidence indicates that oxidative stress is involved in humic acid-induced effects. In the present study, we investigated generation of hydroxyl radicals from humic acid, as well as the effects of humic acid to lung epithelial cells and artificial alveolar lining fluid antioxidant mixture. The involvement of iron in humic acid-induced effects was also determined. We found that humic acid (concentration and time dependently) reduced the cell survival, increased caspase-3 activity, depleted GSH and raised lipid peroxidation in epithelial cells. Humic acid reduced antioxidant levels in the lining fluid antioxidant mix, which could be prevented by adding metal ion chelators. These findings suggest that humic acid causes oxidative stress in lung cells and alveolar lining fluid, which is most likely triggered by hydroxyl radicals produced directly from humic acid. Iron is probably involved in humic acid toxicity. |
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Authors:
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Shufan Qi; Gertjan J M den Hartog; Aalt Bast |
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Publication Detail:
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Type: Journal Article Date: 2008-02-23 |
Journal Detail:
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Title: Environmental toxicology and pharmacology Volume: 26 ISSN: 1382-6689 ISO Abbreviation: Environ. Toxicol. Pharmacol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612020 Medline TA: Environ Toxicol Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 96-101 Citation Subset: - |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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