Document Detail

Damage in canine hearts following defibrillator shocks.
MedLine Citation:
PMID:  3013075     Owner:  NLM     Status:  MEDLINE    
Experiments were performed to investigate possible differences in potential myocardial cell damage following the use of two clinically available difibrillators. One had a damped sine wave (DSW), and the other a truncated exponential waveform (TEW). The latter, therefore, had a lower peak current and voltage. After pilot studies to determine damage potential, an energy content of 10 Joules per kg was selected with three transthoracic shocks at 30 second intervals, delivered with paddles, by both defibrillators. Thirteen dogs were shocked with DSW (10 sacrificed at 24 hours and three at 72 hours). Eleven dogs were shocked with TEW (eight sacrificed at 24 hours and three at 72 hours). Three were used as untreated controls. Observations included ECG monitoring, technetium99m pyrophosphate (Tc-PyP) uptake, and gross and microscopic observations including electron microscopy. This report will concentrate on the morphologic changes. Eleven of 13 dogs shocked with DSW developed ventricular tachycardia, transient heart block, Tc-PyP uptake and myocardial cell death with acute necrosis, and aberrant contraction patterns associated with cell death. Progression of the lesions occurred from 24 to 72 hours. Only two (one at 24 hours and one at 72 hours) of the dogs shocked with TEW showed microscopic foci of necrosis. One was a chance finding (24 hours); the other was associated with an overlying "yellow streak". In neither case were arrhythmias or Tc-PyP uptake observed. The results indicate that in dogs at equivalent energy levels, TEW caused significantly less myocardial damage than DSW.
G Lumb; G J Anderson; M L Kase; D V Woo
Related Documents :
2690645 - Myocardial function in sepsis and endotoxin shock.
16810575 - Inferior wall myocardial infarction with or without right ventricular involvement--trea...
8161395 - Imipramine-provoked paradoxical pheochromocytoma crisis: a case of cardiogenic shock.
16563115 - Early invasive revascularisation for patients critically ill after acute myocardial inf...
9385305 - Coma from long-term overingestion of isoniazid.
15996775 - Intracavitary left ventricular hydatid cysts ruptured during cardiopulmonary resuscitat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  16     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-07-07     Completed Date:  1986-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creatine Kinase / analysis
Diphosphates / diagnostic use
Electric Countershock / adverse effects*
Myocardial Contraction
Myocardium / pathology*,  ultrastructure
Tachycardia / etiology
Technetium / diagnostic use
Technetium Tc 99m Pyrophosphate
Reg. No./Substance:
0/Diphosphates; 0/Technetium Tc 99m Pyrophosphate; 7440-26-8/Technetium; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum thymidine kinase in transplant patients: its relation to cytomegalovirus activity, renal trans...
Next Document:  Uptake of radiolabeled ions in normal and ischemia-damaged brain.