Document Detail

Dalteparin and low-dose aspirin in the prevention of adverse obstetric outcomes in women with inherited thrombophilia.
MedLine Citation:
PMID:  17915061     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the benefit of treatment with dalteparin and low-dose aspirin (ASA) in the prevention of obstetric complications in women with inherited thrombophilia. METHODS: A retrospective chart review identified women who had had at least one pregnancy complicated by severe early-onset preeclampsia, placental abruption, fetal growth restriction (FGR), or fetal death. The following inherited thrombophilias were included: deficiencies of antithrombin, protein C, or protein S, and mutations of factor V Leiden (G1691A), factor II (G20210A), or methylenetetrahydrofolate reductase C677T. RESULTS: The records of 43 women with 110 pregnancies were included in the study. Anticoagulant prophylaxis was administered using dalteparin in 13 pregnancies, ASA with dalteparin in 26, and ASA alone in 11. Dalteparin alone and ASA alone showed equivalent effects in preventing preeclampsia and FGR. Combined dalteparin and ASA significantly decreased the risk of preeclampsia (odds ratio [OR] 0.80; 95% confidence intervals [CI] 0.70-0.91, P = 0.001) and FGR (OR 0.70; 95% CI 0.60-0.82, P = 0.001). CONCLUSION: Data from this retrospective cohort study suggest that combined treatment with dalteparin and ASA decreases the risk of preeclampsia by 20% and the risk of FGR by 30% in women with inherited thrombophilia.
Line Leduc; Emmanuelle Dubois; Larissa Takser; Evelyne Rey; Michèle David
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  29     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  787-93     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Sainte-Justine Hospital, University of Montreal, Montreal QC.
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MeSH Terms
Abruptio Placentae / prevention & control
Anticoagulants / therapeutic use*
Aspirin / therapeutic use*
Dalteparin / therapeutic use*
Drug Therapy, Combination
Fetal Death / prevention & control
Fetal Growth Retardation / prevention & control
Pre-Eclampsia / prevention & control
Pregnancy Complications, Hematologic / prevention & control*
Retrospective Studies
Thrombophilia / complications,  drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Dalteparin; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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