Document Detail

Dairy products, polymorphisms in the vitamin D receptor gene and colorectal adenoma recurrence.
MedLine Citation:
PMID:  18470879     Owner:  NLM     Status:  MEDLINE    
Vitamin D receptor (VDR) activation inhibits proliferation and angiogenesis in the colorectal epithelium, and inhibits metastasis of colorectal tumors. Polymorphisms in the VDR gene alter receptor cellular levels and functioning, and may confer altered susceptibility to colorectal neoplasia. We aimed to investigate the influence of VDR polymorphisms and dietary factors impacting on vitamin D metabolism on colorectal adenoma (CRA) recurrence. Data on dietary intakes of calcium, vitamin D and dairy products were collected from 853 participants in the United Kingdom Colorectal Adenoma Prevention trial, a randomized trial of aspirin and folate for CRA recurrence prevention. The VDR Cdx2, FokI, BsmI, ApaI and TaqI polymorphisms were genotyped in 546 participants with available DNA, and gene-diet interaction analyses performed in 480. Dairy product intake was inversely related to CRA recurrence risk independent of calcium and vitamin D [relative risk (RR) = 0.64; 95% confidence intervals (CIs): 0.47-0.88, for subjects in the highest compared to lowest intake tertile, p(trend) = 0.005]. Milk accounted for 60% of dairy product intake, and on analysis of milk and nonmilk dairy products separately recurrence risk in individuals in the highest tertile of milk intake was half that of lowest tertile individuals (RR = 0.52; 95% CI: 0.38-0.72, p(trend) = 3.2 x 10(-5)), whereas nonmilk dairy products did not influence recurrence. VDR polymorphism genotypes and haplotypes did not directly alter recurrence risk, but the reduction in risk associated with high dairy product intake was confined to individuals with ApaI aA/AA genotype (p(interaction) = 0.02). These findings indicate dairy products, and in particular milk, have chemopreventive activity against CRA recurrence.
Richard A Hubner; Kenneth R Muir; Jo-Fen Liu; Richard F A Logan; Matthew J Grainge; Richard S Houlston;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  123     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-93     Citation Subset:  IM    
Institute of Cancer Research, Section of Cancer Genetics, Sutton SM2 5NG, United Kingdom.
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MeSH Terms
Adenoma / diagnosis,  epidemiology,  genetics*,  prevention & control
Aspirin / therapeutic use
Calcium Compounds / administration & dosage
Colorectal Neoplasms / diagnosis,  epidemiology,  genetics*,  prevention & control
Dairy Products*
Folic Acid / therapeutic use
Great Britain
Middle Aged
Neoplasm Recurrence, Local / epidemiology,  genetics*,  prevention & control
Polymorphism, Genetic*
Randomized Controlled Trials as Topic
Receptors, Calcitriol / genetics*
Risk Assessment
Risk Factors
Transcription Factors / genetics*
Vitamin D / administration & dosage
Reg. No./Substance:
0/Calcium Compounds; 0/Receptors, Calcitriol; 0/Transcription Factors; 0/ZNF410 protein, human; 1406-16-2/Vitamin D; 50-78-2/Aspirin; 59-30-3/Folic Acid
N Armitage / ; V Shepherd / ; C Elliott / ; P Watmough / ; S Barratt / ; N Birch / ; A Gibbons / ; G Campion / ; R Logan / ; N Wright / ; J Patterson / ; A Scott / ; J Reynolds / ; R Walt / ; H Martin / ; B Bisseker / ; N Hudson / ; A Hamlyn / ; M Thomas / ; P Durdey / ; K Green / ; A Roe / ; A Watson / ; K Johnston / ; C Babbs / ; D Shreeve / ; J Crampton / ; C Summerton / ; T Warnes / ; P Isaacs / ; M Rolland / ; A Shorthouse / ; E Heatherington / ; K Hosie / ; K Bardhan / ; K Vellacott / ; A Hawthorne / ; H Thompson-Jones / ; R Stenson / ; P Watson / ; H Lawther /

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