Document Detail


Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study.
MedLine Citation:
PMID:  19710195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Some epidemiologic studies have suggested inverse relations between intake of dairy products and components of the metabolic syndrome. OBJECTIVE: The objective was to investigate the effects of an increased intake of dairy products in persons with a habitually low intake on body composition and factors related to the metabolic syndrome. DESIGN: Middle-aged overweight subjects (n = 121) with traits of the metabolic syndrome were recruited in Finland, Norway, and Sweden and randomly assigned into milk or control groups. The milk group was instructed to consume 3-5 portions of dairy products daily. The control group maintained their habitual diet. Clinical investigations were conducted on admission and after 6 mo. RESULTS: There were no significant differences between changes in body weight or body composition, blood pressure, markers of inflammation, endothelial function, adiponectin, or oxidative stress in the milk and the control groups. There was a modest unfavorable increase in serum cholesterol concentrations in the milk group (P = 0.043). Among participants with a low calcium intake at baseline (<700 mg/d), there was a significant treatment effect for waist circumference (P = 0.003) and sagittal abdominal diameter (P = 0.034). When the sexes were analyzed separately, leptin increased (P = 0.045) and vascular cell adhesion molecule-1 decreased (P = 0.001) in women in the milk group. CONCLUSIONS: This study gives no clear support to the hypothesis that a moderately increased intake of dairy products beneficially affects aspects of the metabolic syndrome. The apparently positive effects on waist circumference and sagittal abdominal diameter in subjects with a low calcium intake suggest a possible threshold in relation to effects on body composition.
Authors:
Marianne Hauge Wennersberg; Annika Smedman; Anu M Turpeinen; Kjetil Retterstøl; Siv Tengblad; Endla Lipre; Antti Aro; Pertti Mutanen; Ingebjørg Seljeflot; Samar Basu; Jan I Pedersen; Marja Mutanen; Bengt Vessby
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-26
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  960-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Nutrition, University of Oslo, Oslo, Norway.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Calcium, Dietary / administration & dosage
Cholesterol / blood
Dairy Products*
Deficiency Diseases / blood
Diet*
Dietary Carbohydrates / pharmacology
Dietary Fats / pharmacology
Dietary Proteins / pharmacology
Female
Finland
Humans
Leptin / blood
Male
Metabolic Syndrome X / blood,  diet therapy*
Middle Aged
Norway
Overweight / blood,  diet therapy*
Sex Factors
Sweden
Vascular Cell Adhesion Molecule-1 / blood
Waist Circumference
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Leptin; 0/Vascular Cell Adhesion Molecule-1; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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