Document Detail

Dairy products, leanness, and head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  18642285     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As part of a population-based case-control study, we investigated the association of food groups and micronutrients estimated from a validated food frequency questionnaire (FFQ) with the risk of development of head and neck squamous cell carcinoma (HNSCC).
METHODS: Incident cases were accrued through Boston area hospitals from 1999 to 2003, and neighborhood controls were selected and matched by location, age, and sex. There were 504 cases and 717 controls enrolled, who completed the FFQ.
RESULTS: We observed a positive association between the consumption of dairy products and HNSCC. The odds of HNSCC in the highest quintile of dairy intake was 1.64 (95% CI: 1.09-2.46), compared with subjects in the lowest quintile. There was a significant association between leanness with HNSCC. The odds of cancer among the leanest subjects was 5.8 (95%CI: 3.2-10.6) compared with a healthy BMI. Finally, intake of animal fat was positively associated with an elevation in cancer risk. The odds of HNSCC for high animal fat intake were 1.50 (0.99-2.27).
CONCLUSIONS: Our data suggest that consumption of fruits and vegetables is not universally protective for HNSCC and that other food groups and nutrients may influence the risk for developing this disease.
Edward S Peters; Brian G Luckett; Katie M Applebaum; Carmen J Marsit; Michael D McClean; Karl T Kelsey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Head & neck     Volume:  30     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-11-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-205     Citation Subset:  IM    
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MeSH Terms
Age Distribution
Aged, 80 and over
Alcohol Drinking / epidemiology
Carcinoma, Squamous Cell / epidemiology,  prevention & control*
Case-Control Studies
Confidence Intervals
Dairy Products / statistics & numerical data*
Head and Neck Neoplasms / epidemiology,  prevention & control*
Micronutrients / administration & dosage
Middle Aged
Primary Prevention / methods
Reference Values
Retrospective Studies
Risk Factors
Sex Distribution
Smoking / epidemiology
Thinness / epidemiology*
Grant Support
CA100679/CA/NCI NIH HHS; CA78609/CA/NCI NIH HHS; R01 CA078609/CA/NCI NIH HHS; R01 CA078609-01A1/CA/NCI NIH HHS; R01 CA078609-06A2/CA/NCI NIH HHS; R01 CA100679/CA/NCI NIH HHS; R01 CA100679-01A1/CA/NCI NIH HHS; T32 ES007155/ES/NIEHS NIH HHS; T32 ES07155/ES/NIEHS NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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