| Dairy milk fat augments paclitaxel therapy to suppress tumour metastasis in mice, and protects against the side-effects of chemotherapy. | |
| | |
MedLine Citation:
|
PMID: 21739249 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Milk fat is a natural product containing essential nutrients as well as fatty acids and other food factors with reported anti-cancer potential. Here bovine milk fat was tested for its ability to inhibit the growth of breast and colon cancers and their metastasis to the lung and liver; either alone or in combination with the chemotherapeutic agent paclitaxel. A diet containing 5% typical anhydrous milk fat (representing ~70% of the total dietary fat component) fed to Balb/c mice delayed the appearance of subcutaneous 4T1 breast and CT26 colon cancer tumours and inhibited their metastasis to the lung and liver, when compared to the control diet containing soybean oil as the only fat component. It augmented the inhibitory effects of paclitaxel on tumour growth and metastasis, and reduced the microvessel density of tumours. It displayed no apparent organ toxicity, but instead was beneficial for well-being of tumour-bearing mice by maintaining gastrocnemius muscle and epididymal adipose tissue that were otherwise depleted by cachexia. The milk fat diet ameliorated gut damage caused by paclitaxel in non-tumour-bearing mice, as evidenced by retention of jejunal morphology, villi length and intestinal γ-glutamyl transpeptidase activity, and inhibition of crypt apoptosis. It prevented loss of red and white blood cells due to both cancer-mediated immunosuppression and the cytotoxic effects of chemotherapy. The present study warrants the use of milk fat as an adjuvant to inhibit tumour metastasis during cancer chemotherapy, and to spare patients from the debilitating side-effects of cytotoxic drugs. |
| | |
Authors:
|
Xueying Sun; Jie Zhang; Rita Gupta; Alastair K H Macgibbon; Barbara Kuhn-Sherlock; Geoffrey W Krissansen |
Related Documents
:
|
8034629 - Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein... 220359 - Changes in plasma very low density and low density lipoprotein content, composition, an... 8978489 - Hypocholesterolemic actions of atorvastatin are associated with alterations on hepatic ... 9643349 - Effects of dietary fish oil on serum lipids and vldl kinetics in hyperlipidemic apolipo... 18442639 - Differential expression of hepatic genes involved in cholesterol homeostasis in high- a... 189159 - Inheritance of type-iii hyperlipoproteinemia. lipoprotein patterns in first-degree rela... 11332509 - The effects of alpha-lactabumin and whey protein concentrate on dry matter recovery, tc... 10885799 - Effect of soy milk and bifidobacterium-fermented soy milk on plasma and liver lipids in... 811179 - Physiological effects of polychlorinated biphenyls or a combination of ddt, ddd, and dd... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-8 |
Journal Detail:
|
Title: Clinical & experimental metastasis Volume: - ISSN: 1573-7276 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8409970 Medline TA: Clin Exp Metastasis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Lactopharma Consortium, University of Auckland, Auckland, New Zealand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 3,5-Diiodo-L-Thyronine increases F(o)F (1)-ATP synthase activity and cardiolipin level in liver mito...
Next Document: Diversity of Arbuscular Mycorrhizal Fungi Associated with Plants Growing in Fly Ash Pond and Their P...