| Daily variations of the involvement of beta-receptors in the sympathetic nerve action on glycogenolysis in perfused rat liver. | |
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MedLine Citation:
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PMID: 1317709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In perfused rat liver perivascular nerve stimulation (7.5 Hz, 20 V, 2 ms, 5 min) at the liver hilus caused an increase in glucose release, a shift of lactate uptake to output and a decrease in arterial, portal and total flow. The influence of the alpha 1-receptor blocker prazosin and the beta-antagonist propranolol on these nerve effects were studied in the isolated rat liver perfused via both the hepatic artery and the portal vein in three experimental series at 9 a.m., at 2 p.m. and at 8 p.m. 1) The nerve stimulation-dependent increase in glucose output was maximal at 9 a.m. (100%), halfmaximal at 2 p.m. (50%) and very low at 8 p.m. (15%). The alterations in arterial, portal and total flow were similar in all three series. 2) At 9 a.m., at 2 p.m. and at 8 p.m. 5 microM arterial plus portal prazosin nearly completely inhibited the metabolic alterations and blocked the reduction of arterial, portal and total flow by 80%. 3) At 9 a.m. 10 microM arterial, portal and arterial plus portal propranolol inhibited the increase in glucose release to less than 25% and the shift of lactate uptake to output to about 50%. At 2 p.m. this inhibitory effect was not observed, neither by selective arterial or portal, nor by simultaneous arterial plus portal addition of 10 microM propranolol. At 8 p.m. the influence of propranolol could not be studied because of the too small control values. The nerve stimulation-dependent reduction of arterial, portal and total flow was not influenced by propranolol, neither at 9 a.m. nor at 2 p.m.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Gardemann; H Beck; K Jungermann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological chemistry Hoppe-Seyler Volume: 373 ISSN: 0177-3593 ISO Abbreviation: Biol. Chem. Hoppe-Seyler Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-07-09 Completed Date: 1992-07-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503054 Medline TA: Biol Chem Hoppe Seyler Country: GERMANY |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
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Institut für Biochemie, Fachbereich Medizin, Universität, Göttingen. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Circadian Rhythm* / drug effects Hemodynamics / drug effects Lactates / metabolism Lactic Acid Liver / blood supply, drug effects, innervation* Liver Circulation* / drug effects Liver Glycogen / drug effects, metabolism* Male Perfusion Prazosin / pharmacology Propranolol / pharmacology Rats Rats, Inbred Strains Receptors, Adrenergic, beta / drug effects, metabolism, physiology* Signal Transduction Sympathetic Nervous System / blood supply, drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Lactates; 0/Liver Glycogen; 0/Receptors, Adrenergic, beta; 19216-56-9/Prazosin; 50-21-5/Lactic Acid; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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